Effect of different remineralizing agents on the initial carious lesions – A comparative study
Objectives: This study aimed to assess and compare the effectiveness of three different remineralizing agents (Tricalcium phosphate paste, Fluoride varnish, and Nano-hydroxyapatite gel) using the DIAGNOdent device. Material and Methods: The present clinical study was carried out on 90 initial cariou...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2020-12-01
|
| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905219308120 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683969032847360 |
|---|---|
| author | Mohammed Alhamed Faisal Almalki Ahmad Alselami Tariq Alotaibi Wahdan Elkwatehy |
| author_facet | Mohammed Alhamed Faisal Almalki Ahmad Alselami Tariq Alotaibi Wahdan Elkwatehy |
| author_sort | Mohammed Alhamed |
| collection | DOAJ |
| description | Objectives: This study aimed to assess and compare the effectiveness of three different remineralizing agents (Tricalcium phosphate paste, Fluoride varnish, and Nano-hydroxyapatite gel) using the DIAGNOdent device. Material and Methods: The present clinical study was carried out on 90 initial carious lesions detected by ICDAS caries diagnostic criteria and then take the baseline record by DIAGNOdent device. The selected initial carious lesions were randomly classified into three groups according to treatment modalities (30 lesions in each group) according to remineralizing agents: group A (TCP), group B (fluoride varnish) and group C (nano-hydroxyapatite gel). The remineralizing agents were applied for four minutes once weekly for four weeks. At the fifth week, the DIAGNOdent scores of initial carious lesions were recorded to evaluate the effect of remineralizing agents. A paired t-test was used to compare between baseline date and follow up of DIAGNOdent scores. A one-way ANOVA test was used to compare DIAGNOdent scores among the three groups. Post- Hoc Tukey test was used to determine the significant difference between every two groups. Results: There were statistically significant differences among the three groups at follow up (p = 0.001). Within each group, there was a significant difference between baseline and follow up scores (p = 0.000 for the three groups). Multiple comparisons between every two groups showed a highly statistically significant difference at follow up records between nano-hydroxyapatite versus TCP and fluoride varnish on pit and fissure caries (p = 0.039 and p = 0.007 respectively) and the nano-hydroxyapatite was the best of them. Conclusion: The present study concluded that the three remineralizing agents were effective in the treatment of initial carious lesion and the most effective remineralizing agent was nano-hydroxyapatite. |
| format | Article |
| id | doaj-art-cbbbafd9828b458a81aacf17da3104f9 |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-cbbbafd9828b458a81aacf17da3104f92025-08-20T03:23:37ZengSpringerSaudi Dental Journal1013-90522020-12-0132839039510.1016/j.sdentj.2019.11.001Effect of different remineralizing agents on the initial carious lesions – A comparative studyMohammed Alhamed0Faisal Almalki1Ahmad Alselami2Tariq Alotaibi3Wahdan Elkwatehy4Faculty of Dentistry, Umm Al-Qura University, Saudi Arabia; Corresponding author at: College of Dentistry, Umm Al-Qura University, P.O. Box 2653, Makkah 24351, Saudi Arabia.Faculty of Dentistry, Umm Al-Qura University, Saudi ArabiaFaculty of Dentistry, Umm Al-Qura University, Saudi ArabiaFaculty of Dentistry, Umm Al-Qura University, Saudi ArabiaFaculty of Dentistry, Umm Al-Qura University, Saudi Arabia; Department of Pediatric, Dental Public Health and Preventive Dentistry, Faculty of Dentistry, Mansoura University, EgyptObjectives: This study aimed to assess and compare the effectiveness of three different remineralizing agents (Tricalcium phosphate paste, Fluoride varnish, and Nano-hydroxyapatite gel) using the DIAGNOdent device. Material and Methods: The present clinical study was carried out on 90 initial carious lesions detected by ICDAS caries diagnostic criteria and then take the baseline record by DIAGNOdent device. The selected initial carious lesions were randomly classified into three groups according to treatment modalities (30 lesions in each group) according to remineralizing agents: group A (TCP), group B (fluoride varnish) and group C (nano-hydroxyapatite gel). The remineralizing agents were applied for four minutes once weekly for four weeks. At the fifth week, the DIAGNOdent scores of initial carious lesions were recorded to evaluate the effect of remineralizing agents. A paired t-test was used to compare between baseline date and follow up of DIAGNOdent scores. A one-way ANOVA test was used to compare DIAGNOdent scores among the three groups. Post- Hoc Tukey test was used to determine the significant difference between every two groups. Results: There were statistically significant differences among the three groups at follow up (p = 0.001). Within each group, there was a significant difference between baseline and follow up scores (p = 0.000 for the three groups). Multiple comparisons between every two groups showed a highly statistically significant difference at follow up records between nano-hydroxyapatite versus TCP and fluoride varnish on pit and fissure caries (p = 0.039 and p = 0.007 respectively) and the nano-hydroxyapatite was the best of them. Conclusion: The present study concluded that the three remineralizing agents were effective in the treatment of initial carious lesion and the most effective remineralizing agent was nano-hydroxyapatite.http://www.sciencedirect.com/science/article/pii/S1013905219308120DIAGNOdentFluoride varnishIn vivoInitial cariesNano-hydroxyapatiteTri-calcium phosphate |
| spellingShingle | Mohammed Alhamed Faisal Almalki Ahmad Alselami Tariq Alotaibi Wahdan Elkwatehy Effect of different remineralizing agents on the initial carious lesions – A comparative study Saudi Dental Journal DIAGNOdent Fluoride varnish In vivo Initial caries Nano-hydroxyapatite Tri-calcium phosphate |
| title | Effect of different remineralizing agents on the initial carious lesions – A comparative study |
| title_full | Effect of different remineralizing agents on the initial carious lesions – A comparative study |
| title_fullStr | Effect of different remineralizing agents on the initial carious lesions – A comparative study |
| title_full_unstemmed | Effect of different remineralizing agents on the initial carious lesions – A comparative study |
| title_short | Effect of different remineralizing agents on the initial carious lesions – A comparative study |
| title_sort | effect of different remineralizing agents on the initial carious lesions a comparative study |
| topic | DIAGNOdent Fluoride varnish In vivo Initial caries Nano-hydroxyapatite Tri-calcium phosphate |
| url | http://www.sciencedirect.com/science/article/pii/S1013905219308120 |
| work_keys_str_mv | AT mohammedalhamed effectofdifferentremineralizingagentsontheinitialcariouslesionsacomparativestudy AT faisalalmalki effectofdifferentremineralizingagentsontheinitialcariouslesionsacomparativestudy AT ahmadalselami effectofdifferentremineralizingagentsontheinitialcariouslesionsacomparativestudy AT tariqalotaibi effectofdifferentremineralizingagentsontheinitialcariouslesionsacomparativestudy AT wahdanelkwatehy effectofdifferentremineralizingagentsontheinitialcariouslesionsacomparativestudy |