Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial

Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial

Abstract Background African children with severe malaria are at increased risk of non-typhoidal salmonellae co-infection. Broad-spectrum antibiotics are recommended by guidelines but the optimal class and dose have not been established. We investigated the optimal dose of oral dispersible azithromyc...

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Main Authors: Roisin Connon, Peter Olupot-Olupot, Arthur M. A. Pistorius, William Okiror, Tonny Ssenyondo, Rita Muhindo, Sophie Uyoga, Ayub Mpoya, Thomas N. Williams, Diana M. Gibb, A. Sarah Walker, Rob ter Heine, Elizabeth C. George, Kathryn Maitland
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Medicine
Subjects:
Severe malaria
African children
Bacterial infection
Pharmacokinetics
Clinical trial
Online Access:https://doi.org/10.1186/s12916-024-03712-5
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