Identification of cellular factors associated with inflammation and neurodegeneration in multiple sclerosis

Identification of cellular factors associated with inflammation and neurodegeneration in multiple sclerosis

BackgroundSerum biomarkers as neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) enabled early identification of multiple sclerosis (MS) patients at risk of relapse-associated worsening (RAW) or progression independent of relapses (PIRA). However, the immunological mechanis...

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Main Authors: Alexander Rodero-Romero, José Ignacio Fernández-Velasco, Enric Monreal, Raquel Sainz-Amo, Roberto Álvarez-Lafuente, Manuel Comabella, Lluís Ramió-Torrentà, José M. García-Domínguez, Noelia Villarrubia, Susana Sainz de la Maza, María Domínguez-Mozo, Ana Quiroga-Varela, Juan Luís Chico-García, Fernando Rodriguez-Jorge, José Luis Veiga-Gonzalez, Ernesto Roldán-Santiago, Mercedes Espiño, Eulalia Rodríguez-Martín, Gary Álvarez, Jaime Masjuan, Xavier Montalban, Lucienne Costa-Frossard, Luisa María Villar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
serum biomarkers
cellular phenotype and function
neurofilament light chain
glial fibrillary acidic protein
demyelinating disease of central nervous system
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648725/full
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