The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies

As the dental implant restoration technology is constantly applied and developed, implant fracture and related infections have emerged as significant factors threatening the long-term outcome of implants. Hence, this experiment intends to bestow the implant itself with anti-fracture and antibacteria...

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Main Authors: Ying Liu, Chenyang Niu, Minghui Chu, Mingda Liu, Yanxia Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oral Health
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Online Access:https://www.frontiersin.org/articles/10.3389/froh.2025.1565325/full
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author Ying Liu
Ying Liu
Chenyang Niu
Chenyang Niu
Minghui Chu
Mingda Liu
Yanxia Chi
author_facet Ying Liu
Ying Liu
Chenyang Niu
Chenyang Niu
Minghui Chu
Mingda Liu
Yanxia Chi
author_sort Ying Liu
collection DOAJ
description As the dental implant restoration technology is constantly applied and developed, implant fracture and related infections have emerged as significant factors threatening the long-term outcome of implants. Hence, this experiment intends to bestow the implant itself with anti-fracture and antibacterial capabilities by utilizing ultrafine-grained titanium, which possesses relatively superior mechanical properties, as the implant material and depositing a graphene oxide-minocycline composite coating on its surface. This is done to prevent implant fracture and the initial attachment of early microorganisms, and to strive to impede the colonization of late microorganisms and the formation of infectious biofilms, thereby achieving long-term stability of the implant. The graphene oxide-minocycline composite coating can be successfully fabricated on the surface of ultrafine-grained titanium via electrochemical deposition and liquid-phase deposition techniques, which can enhance the hydrophilicity of ultrafine-grained titanium and exhibit good coating adhesion. It demonstrates excellent antibacterial properties against Staphylococcus aureus, has no in vitro hemolysis, and shows no obvious cytotoxicity to mouse pre-osteoblasts.
format Article
id doaj-art-cbacd573df434247b48e334ba12b6fb1
institution OA Journals
issn 2673-4842
language English
publishDate 2025-04-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Oral Health
spelling doaj-art-cbacd573df434247b48e334ba12b6fb12025-08-20T02:24:59ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-04-01610.3389/froh.2025.15653251565325The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studiesYing Liu0Ying Liu1Chenyang Niu2Chenyang Niu3Minghui Chu4Mingda Liu5Yanxia Chi6Stomatology Collage of Jiamusi University, Jiamusi, Heilongjiang, ChinaKey Laboratory of Oral Biomedical Materials and Clinical Application, Jiamusi, Heilongjiang, ChinaStomatology Collage of Jiamusi University, Jiamusi, Heilongjiang, ChinaKey Laboratory of Oral Biomedical Materials and Clinical Application, Jiamusi, Heilongjiang, ChinaThe Second Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, ChinaThe Second Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, ChinaThe Second Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, ChinaAs the dental implant restoration technology is constantly applied and developed, implant fracture and related infections have emerged as significant factors threatening the long-term outcome of implants. Hence, this experiment intends to bestow the implant itself with anti-fracture and antibacterial capabilities by utilizing ultrafine-grained titanium, which possesses relatively superior mechanical properties, as the implant material and depositing a graphene oxide-minocycline composite coating on its surface. This is done to prevent implant fracture and the initial attachment of early microorganisms, and to strive to impede the colonization of late microorganisms and the formation of infectious biofilms, thereby achieving long-term stability of the implant. The graphene oxide-minocycline composite coating can be successfully fabricated on the surface of ultrafine-grained titanium via electrochemical deposition and liquid-phase deposition techniques, which can enhance the hydrophilicity of ultrafine-grained titanium and exhibit good coating adhesion. It demonstrates excellent antibacterial properties against Staphylococcus aureus, has no in vitro hemolysis, and shows no obvious cytotoxicity to mouse pre-osteoblasts.https://www.frontiersin.org/articles/10.3389/froh.2025.1565325/fullgraphene oxideultrafine-grained titaniumelectrochemical depositionminocyclineantibacterialcytocompatibility
spellingShingle Ying Liu
Ying Liu
Chenyang Niu
Chenyang Niu
Minghui Chu
Mingda Liu
Yanxia Chi
The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies
Frontiers in Oral Health
graphene oxide
ultrafine-grained titanium
electrochemical deposition
minocycline
antibacterial
cytocompatibility
title The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies
title_full The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies
title_fullStr The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies
title_full_unstemmed The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies
title_short The preparation and characterization of graphene oxide-multiwalled minocycline coatings on ultrafine-grained titanium implants for enhanced performance studies
title_sort preparation and characterization of graphene oxide multiwalled minocycline coatings on ultrafine grained titanium implants for enhanced performance studies
topic graphene oxide
ultrafine-grained titanium
electrochemical deposition
minocycline
antibacterial
cytocompatibility
url https://www.frontiersin.org/articles/10.3389/froh.2025.1565325/full
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