The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little

The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little

Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms. The presented study aimed to investigate the behaviour of gelatine a...

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Bibliographic Details
Main Authors: Dorota Sarwinska, Mathilde Leyh, Constantin Foja, Theodora Tzakri, Philipp Schick, Felix Morof, Julius Krause, James Mann, Richard Barker, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Pharmaceutics: X
Subjects:
Capsules
Pharmacokinetics
Black tea
Temperature effect
USP 2
GastroDuo
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156725000271
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