A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer
Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is an accepted treatment for transitional cell carcinoma of the bladder. Carcinoma in situ of the bladder progresses to invasive muscular disease in approximately 54% of untreated patients, mandating early initiation of therapy once the diagn...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2010/572410 |
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| author | Colin B Josephson Saleh Al-Azri Daniel J Smyth David Haase B Lynn Johnston |
| author_facet | Colin B Josephson Saleh Al-Azri Daniel J Smyth David Haase B Lynn Johnston |
| author_sort | Colin B Josephson |
| collection | DOAJ |
| description | Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is an accepted treatment for transitional cell carcinoma of the bladder. Carcinoma in situ of the bladder progresses to invasive muscular disease in approximately 54% of untreated patients, mandating early initiation of therapy once the diagnosis is confirmed. Should BCG treatment fail, an additional course of BCG combined with interferon-alpha, both administered intravesically, is a promising second-line immunotherapy. In greater than 95% of patients, BCG is tolerated without significant morbidity or mortality. However, both early (within three months of the original treatment) and late presentations of systemic infection resulting from intravesical BCG treatment have been described. The present study describes the course of a 75-year-old man with a late presentation of BCG vertebral osteomyelitis, discitis, epidural abscess, bilateral psoas abscesses and probable cerebral tuberculoma, following treatment regimens of intravesical BCG followed by intravesical BCG plus interferon-alpha 2b. |
| format | Article |
| id | doaj-art-cbaa547a1919452f907ecffb86ecf6ca |
| institution | OA Journals |
| issn | 1712-9532 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-cbaa547a1919452f907ecffb86ecf6ca2025-08-20T02:19:47ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322010-01-01211e75e7810.1155/2010/572410A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder CancerColin B Josephson0Saleh Al-Azri1Daniel J Smyth2David Haase3B Lynn Johnston4Divisions of Neurology, Dalhousie University, Halifax, Nova Scotia, CanadaInfectious Disease, Dalhousie University, Halifax, Nova Scotia, CanadaDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia, CanadaInfectious Disease, Dalhousie University, Halifax, Nova Scotia, CanadaInfectious Disease, Dalhousie University, Halifax, Nova Scotia, CanadaIntravesical Bacillus Calmette-Guérin (BCG) immunotherapy is an accepted treatment for transitional cell carcinoma of the bladder. Carcinoma in situ of the bladder progresses to invasive muscular disease in approximately 54% of untreated patients, mandating early initiation of therapy once the diagnosis is confirmed. Should BCG treatment fail, an additional course of BCG combined with interferon-alpha, both administered intravesically, is a promising second-line immunotherapy. In greater than 95% of patients, BCG is tolerated without significant morbidity or mortality. However, both early (within three months of the original treatment) and late presentations of systemic infection resulting from intravesical BCG treatment have been described. The present study describes the course of a 75-year-old man with a late presentation of BCG vertebral osteomyelitis, discitis, epidural abscess, bilateral psoas abscesses and probable cerebral tuberculoma, following treatment regimens of intravesical BCG followed by intravesical BCG plus interferon-alpha 2b.http://dx.doi.org/10.1155/2010/572410 |
| spellingShingle | Colin B Josephson Saleh Al-Azri Daniel J Smyth David Haase B Lynn Johnston A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer |
| title_full | A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer |
| title_fullStr | A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer |
| title_full_unstemmed | A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer |
| title_short | A Case of Pott’s Disease with Epidural Abscess and Probable Cerebral Tuberculoma following Bacillus Calmette-Guérin Therapy for Superficial Bladder Cancer |
| title_sort | case of pott s disease with epidural abscess and probable cerebral tuberculoma following bacillus calmette guerin therapy for superficial bladder cancer |
| url | http://dx.doi.org/10.1155/2010/572410 |
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