Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy
Abstract The aim of this study is to evaluate the effect of obesity on robotic-assisted radical prostatectomy (RARP) outcomes. This study included 120 obese patients [body mass index (BMI) ≥ 30 kg/m²] and 124 normal weight (BMI ≤ 25 kg/m²)] patients from a total of 750 patients who underwent RARP be...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82003-8 |
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| author | Sahin Kilic Murat Sambel |
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| description | Abstract The aim of this study is to evaluate the effect of obesity on robotic-assisted radical prostatectomy (RARP) outcomes. This study included 120 obese patients [body mass index (BMI) ≥ 30 kg/m²] and 124 normal weight (BMI ≤ 25 kg/m²)] patients from a total of 750 patients who underwent RARP between January 2017 and March 2023. The perioperative and long-term oncological and functional outcomes were also analyzed. No significant differences were observed between the groups regarding age, prostate-specific antigen (PSA) levels, or International Society of Urological Pathology (ISUP) grade distribution (p > 0.05). The obese group had significantly longer median surgical times, vesicourethral anastomosis times, hospital stays and drain removal times compared to the control group (p < 0.05). The control group demonstrated significantly better continence recovery rate at the 1st month and erectile dysfunction (ED) recovery rate at the 12th month (p < 0.05). Bilateral nerve sparing (OR: 16.59; p < 0.001) and the preoperative IIEF score (OR: 1.29; p < 0.001) were identified as independent predictors of ED recovery in the multivariable logistic regression model. Bilateral nerve sparing (OR: 3.00; p < 0.001) and the absence of metabolic syndrome (OR: 2.03; p < 0.05) were found to be independent predictors of early continence recovery. There were no differences in systemic progression or overall survival at a median follow-up of 24 months (p > 0.05). While obesity adversely impacts perioperative outcomes, short-term continence recovery rates, and mid-term ED recovery rates, it does not affect mid-term oncological outcomes after RARP. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-cba55dc23b974a51beda0183b41c8f942025-01-05T12:19:57ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-82003-8Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical ProstatectomySahin Kilic0Murat Sambel1Department of Urology, Antalya Training and Research HospitalDepartment of Urology, Antalya Training and Research HospitalAbstract The aim of this study is to evaluate the effect of obesity on robotic-assisted radical prostatectomy (RARP) outcomes. This study included 120 obese patients [body mass index (BMI) ≥ 30 kg/m²] and 124 normal weight (BMI ≤ 25 kg/m²)] patients from a total of 750 patients who underwent RARP between January 2017 and March 2023. The perioperative and long-term oncological and functional outcomes were also analyzed. No significant differences were observed between the groups regarding age, prostate-specific antigen (PSA) levels, or International Society of Urological Pathology (ISUP) grade distribution (p > 0.05). The obese group had significantly longer median surgical times, vesicourethral anastomosis times, hospital stays and drain removal times compared to the control group (p < 0.05). The control group demonstrated significantly better continence recovery rate at the 1st month and erectile dysfunction (ED) recovery rate at the 12th month (p < 0.05). Bilateral nerve sparing (OR: 16.59; p < 0.001) and the preoperative IIEF score (OR: 1.29; p < 0.001) were identified as independent predictors of ED recovery in the multivariable logistic regression model. Bilateral nerve sparing (OR: 3.00; p < 0.001) and the absence of metabolic syndrome (OR: 2.03; p < 0.05) were found to be independent predictors of early continence recovery. There were no differences in systemic progression or overall survival at a median follow-up of 24 months (p > 0.05). While obesity adversely impacts perioperative outcomes, short-term continence recovery rates, and mid-term ED recovery rates, it does not affect mid-term oncological outcomes after RARP.https://doi.org/10.1038/s41598-024-82003-8Metabolic syndromeObesityProstate cancerRadical prostatectomyRobotic-assisted |
| spellingShingle | Sahin Kilic Murat Sambel Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy Scientific Reports Metabolic syndrome Obesity Prostate cancer Radical prostatectomy Robotic-assisted |
| title | Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy |
| title_full | Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy |
| title_fullStr | Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy |
| title_full_unstemmed | Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy |
| title_short | Impact of Obesity on Perioperative and Clinical Outcomes After Robotic Assisted Radical Prostatectomy |
| title_sort | impact of obesity on perioperative and clinical outcomes after robotic assisted radical prostatectomy |
| topic | Metabolic syndrome Obesity Prostate cancer Radical prostatectomy Robotic-assisted |
| url | https://doi.org/10.1038/s41598-024-82003-8 |
| work_keys_str_mv | AT sahinkilic impactofobesityonperioperativeandclinicaloutcomesafterroboticassistedradicalprostatectomy AT muratsambel impactofobesityonperioperativeandclinicaloutcomesafterroboticassistedradicalprostatectomy |