Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients
Objective To explore the relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis(MHD) patients.Methods 144 MHD patients(MHD group) and 29 normal cases(control group) were enrolled.According to hemodialysis age,MHD group was d...
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Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | MIAO Shi-mei FAN Ya-ping XU Xue-kang QIAN Tong-sun |
| author_facet | MIAO Shi-mei FAN Ya-ping XU Xue-kang QIAN Tong-sun |
| author_sort | MIAO Shi-mei |
| collection | DOAJ |
| description | Objective To explore the relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis(MHD) patients.Methods 144 MHD patients(MHD group) and 29 normal cases(control group) were enrolled.According to hemodialysis age,MHD group was divided into four subgroups:MHD-1 subgroup(n=45,hemodialysis age of 3~24 months);MHD-2 subgroup(n=41,hemodialysis age of 25~60 months);MHD-3 subgroup(n=37,hemodialysis age of 61~120 months),and MHD-4 subgroup(n=21,hemodialysis age of over 120 months).Serum AOPP,IL-6,TNF-α and CRP levels were measured.The relationship between the markers of oxidative stress and micro-inflammatory state,and the relationship between all these markers and hemodialysis age were analyzed.Statistical analysis was conducted with one-way ANOVA,t test and pearson’s correlation.Results(1)Serum AOPP in MHD patients was significantly higher than in controls(P<0.05);(2)Serum CRP in MHD patients was significantly higher than in controls too(P<0.05),and IL-6 and TNF-α levels in MHD-2-4 subgroups were significantly higher than those in controls(P<0.05);(3) AOPP was positively correlated with CRP,IL-6,and TNF-α(P<0.01);(4) AOPP and CRP,IL-6,TNF-α in MHD patients were positively correlated to their hemodialysis age(P<0.01).Conclusions There are oxidative stress and micro-inflammatory states in MHD patients.There is a intimate relationship between oxidative stress and micro-inflammation in MHD patients.With hemodialysis age prolonged,the levels of oxidative stress and micro-inflammation in MHD patients became more severer. |
| format | Article |
| id | doaj-art-cba266c68ef74e9abd060556b5ee98df |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2016-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-cba266c68ef74e9abd060556b5ee98df2025-08-20T02:28:49ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902016-01-0134534957918922Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patientsMIAO Shi-meiFAN Ya-pingXU Xue-kangQIAN Tong-sunObjective To explore the relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis(MHD) patients.Methods 144 MHD patients(MHD group) and 29 normal cases(control group) were enrolled.According to hemodialysis age,MHD group was divided into four subgroups:MHD-1 subgroup(n=45,hemodialysis age of 3~24 months);MHD-2 subgroup(n=41,hemodialysis age of 25~60 months);MHD-3 subgroup(n=37,hemodialysis age of 61~120 months),and MHD-4 subgroup(n=21,hemodialysis age of over 120 months).Serum AOPP,IL-6,TNF-α and CRP levels were measured.The relationship between the markers of oxidative stress and micro-inflammatory state,and the relationship between all these markers and hemodialysis age were analyzed.Statistical analysis was conducted with one-way ANOVA,t test and pearson’s correlation.Results(1)Serum AOPP in MHD patients was significantly higher than in controls(P<0.05);(2)Serum CRP in MHD patients was significantly higher than in controls too(P<0.05),and IL-6 and TNF-α levels in MHD-2-4 subgroups were significantly higher than those in controls(P<0.05);(3) AOPP was positively correlated with CRP,IL-6,and TNF-α(P<0.01);(4) AOPP and CRP,IL-6,TNF-α in MHD patients were positively correlated to their hemodialysis age(P<0.01).Conclusions There are oxidative stress and micro-inflammatory states in MHD patients.There is a intimate relationship between oxidative stress and micro-inflammation in MHD patients.With hemodialysis age prolonged,the levels of oxidative stress and micro-inflammation in MHD patients became more severer.http://www.lcszb.com/thesisDetails?columnId=57918922&Fpath=home&index=0Maintenance hemodialysisOxidative stressMicro inflammation |
| spellingShingle | MIAO Shi-mei FAN Ya-ping XU Xue-kang QIAN Tong-sun Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients Linchuang shenzangbing zazhi Maintenance hemodialysis Oxidative stress Micro inflammation |
| title | Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients |
| title_full | Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients |
| title_fullStr | Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients |
| title_full_unstemmed | Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients |
| title_short | Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients |
| title_sort | clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro inflammatory state in maintenance hemodialysis patients |
| topic | Maintenance hemodialysis Oxidative stress Micro inflammation |
| url | http://www.lcszb.com/thesisDetails?columnId=57918922&Fpath=home&index=0 |
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