Clinical analysis on relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis patients
Objective To explore the relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis(MHD) patients.Methods 144 MHD patients(MHD group) and 29 normal cases(control group) were enrolled.According to hemodialysis age,MHD group was d...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57918922&Fpath=home&index=0 |
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| Summary: | Objective To explore the relationship between hemodialysis age and the markers of oxidative stress and micro-inflammatory state in maintenance hemodialysis(MHD) patients.Methods 144 MHD patients(MHD group) and 29 normal cases(control group) were enrolled.According to hemodialysis age,MHD group was divided into four subgroups:MHD-1 subgroup(n=45,hemodialysis age of 3~24 months);MHD-2 subgroup(n=41,hemodialysis age of 25~60 months);MHD-3 subgroup(n=37,hemodialysis age of 61~120 months),and MHD-4 subgroup(n=21,hemodialysis age of over 120 months).Serum AOPP,IL-6,TNF-α and CRP levels were measured.The relationship between the markers of oxidative stress and micro-inflammatory state,and the relationship between all these markers and hemodialysis age were analyzed.Statistical analysis was conducted with one-way ANOVA,t test and pearson’s correlation.Results(1)Serum AOPP in MHD patients was significantly higher than in controls(P<0.05);(2)Serum CRP in MHD patients was significantly higher than in controls too(P<0.05),and IL-6 and TNF-α levels in MHD-2-4 subgroups were significantly higher than those in controls(P<0.05);(3) AOPP was positively correlated with CRP,IL-6,and TNF-α(P<0.01);(4) AOPP and CRP,IL-6,TNF-α in MHD patients were positively correlated to their hemodialysis age(P<0.01).Conclusions There are oxidative stress and micro-inflammatory states in MHD patients.There is a intimate relationship between oxidative stress and micro-inflammation in MHD patients.With hemodialysis age prolonged,the levels of oxidative stress and micro-inflammation in MHD patients became more severer. |
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| ISSN: | 1671-2390 |