Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration
<b>Background/Objectives:</b> Mometasone furoate (MF) is a topical corticosteroid used to reduce allergic and inflammation symptoms. In this study, MF was incorporated into the hydrophobic cavities of γ-cyclodextrin metal-organic frameworks (CD-MOFs) to prepare MF@MOF powders for nasal d...
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2025-06-01
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| Online Access: | https://www.mdpi.com/1999-4923/17/6/788 |
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| author | Jie Li Yuhua Guo Yan Liu Qingfang Gao Siwen Wang Li Wu Caifen Wang Xiaohong Ren Jiwen Zhang |
| author_facet | Jie Li Yuhua Guo Yan Liu Qingfang Gao Siwen Wang Li Wu Caifen Wang Xiaohong Ren Jiwen Zhang |
| author_sort | Jie Li |
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| description | <b>Background/Objectives:</b> Mometasone furoate (MF) is a topical corticosteroid used to reduce allergic and inflammation symptoms. In this study, MF was incorporated into the hydrophobic cavities of γ-cyclodextrin metal-organic frameworks (CD-MOFs) to prepare MF@MOF powders for nasal delivery. <b>Methods</b>: MF@MOF particles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetry. A transparent biomimetic model of the human nasal cavity was produced by 3D printing and used to evaluate intra-nasal depositions patterns. <b>Results</b>: Drug loading was optimized by incubating MF with a CD-MOF at a ratio of 4% for 1 h at 40 °C, and the cubic morphology and particle size of the nanoparticles were not altered using an incubation method. PXRD and FTIR analyses confirmed the successful loading of MF into the CD-MOF. Using a 3D biomimetic nasal cavity model, a 30° administration angle was found to result in reduced drug accumulation in the nasal vestibule and enhanced deposition in the respiratory and olfactory regions, compared with administration at 45°. Approximately 51% of the drug reached the respiratory zone in the model of the nasal cavity from male subjects, while almost 60% of the drug reached this zone in the model associated with female subjects. Compared with nasal sprays, nasal powder sprays had less deposition in the nasal vestibule and more deposits in the middle and inferior nasal concha. <b>Conclusions</b>: MF@MOF is suitable for intranasal administration. Delivery of MF as a nasal powder shows potential in the treatment of chronic rhinosinusitis. |
| format | Article |
| id | doaj-art-cba0c001a26c4e828a3227a60608dc93 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-cba0c001a26c4e828a3227a60608dc932025-08-20T02:21:50ZengMDPI AGPharmaceutics1999-49232025-06-0117678810.3390/pharmaceutics17060788Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal AdministrationJie Li0Yuhua Guo1Yan Liu2Qingfang Gao3Siwen Wang4Li Wu5Caifen Wang6Xiaohong Ren7Jiwen Zhang8Biological and Pharmaceutical Sciences, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, ChinaYangtze Delta Drug Advanced Research Institute, Nantong 226126, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, ChinaYangtze Delta Drug Advanced Research Institute, Nantong 226126, China<b>Background/Objectives:</b> Mometasone furoate (MF) is a topical corticosteroid used to reduce allergic and inflammation symptoms. In this study, MF was incorporated into the hydrophobic cavities of γ-cyclodextrin metal-organic frameworks (CD-MOFs) to prepare MF@MOF powders for nasal delivery. <b>Methods</b>: MF@MOF particles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetry. A transparent biomimetic model of the human nasal cavity was produced by 3D printing and used to evaluate intra-nasal depositions patterns. <b>Results</b>: Drug loading was optimized by incubating MF with a CD-MOF at a ratio of 4% for 1 h at 40 °C, and the cubic morphology and particle size of the nanoparticles were not altered using an incubation method. PXRD and FTIR analyses confirmed the successful loading of MF into the CD-MOF. Using a 3D biomimetic nasal cavity model, a 30° administration angle was found to result in reduced drug accumulation in the nasal vestibule and enhanced deposition in the respiratory and olfactory regions, compared with administration at 45°. Approximately 51% of the drug reached the respiratory zone in the model of the nasal cavity from male subjects, while almost 60% of the drug reached this zone in the model associated with female subjects. Compared with nasal sprays, nasal powder sprays had less deposition in the nasal vestibule and more deposits in the middle and inferior nasal concha. <b>Conclusions</b>: MF@MOF is suitable for intranasal administration. Delivery of MF as a nasal powder shows potential in the treatment of chronic rhinosinusitis.https://www.mdpi.com/1999-4923/17/6/788mometasone furoatecyclodextrin metal-organic frameworknasal powder spraythree-dimensional biomimetic model of the human nasal cavity |
| spellingShingle | Jie Li Yuhua Guo Yan Liu Qingfang Gao Siwen Wang Li Wu Caifen Wang Xiaohong Ren Jiwen Zhang Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration Pharmaceutics mometasone furoate cyclodextrin metal-organic framework nasal powder spray three-dimensional biomimetic model of the human nasal cavity |
| title | Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration |
| title_full | Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration |
| title_fullStr | Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration |
| title_full_unstemmed | Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration |
| title_short | Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration |
| title_sort | incorporation of mometasone furoate into a cyclodextrin metal organic framework to optimize nasal administration |
| topic | mometasone furoate cyclodextrin metal-organic framework nasal powder spray three-dimensional biomimetic model of the human nasal cavity |
| url | https://www.mdpi.com/1999-4923/17/6/788 |
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