Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation
Abstract TERT promoter mutation is associated with poor prognosis in differentiated thyroid carcinoma, with US features varying by mutation status. However, this correlation in anaplastic thyroid carcinoma (ATC) is understudied. We investigated the association between clinicopathological characteris...
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Nature Portfolio
2025-04-01
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| author | Haejung Kim Goeun Park Myoung Kyoung Kim Young Lyun Oh Tae Hyuk Kim Jung Hee Shin Soo Yeon Hahn |
| author_facet | Haejung Kim Goeun Park Myoung Kyoung Kim Young Lyun Oh Tae Hyuk Kim Jung Hee Shin Soo Yeon Hahn |
| author_sort | Haejung Kim |
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| description | Abstract TERT promoter mutation is associated with poor prognosis in differentiated thyroid carcinoma, with US features varying by mutation status. However, this correlation in anaplastic thyroid carcinoma (ATC) is understudied. We investigated the association between clinicopathological characteristics and US features of ATC with TERT mutation status and prognosis. From November 1994 to May 2022, 58 ATC nodules from 58 patients were analyzed. Two radiologists retrospectively reviewed US features based on the revised K-TIRADS and ACR-TIRADS. Of all 58 ATC nodules, 32 nodules were tested for TERT promoter mutation and detected in 11. TERT promoter-mutated ATC was larger than TERT wild-type ATC (p = 0.032); however, no other differences were observed. ATC with survival period of less than 12 months were more likely to have lymph node metastasis (p = 0.012) or distant metastasis at diagnosis (p < 0.001), larger size on US (p = 0.005), and suspicion for gross extrathyroidal extension on US (p = 0.04) compared to ATC with survival period of 12 months or more. Advanced disease at diagnosis was a critical factor associated with 1-year survival in patients with ATC, whereas the TERT promoter mutation status was not. |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-cb9d0b2f95434a7c80e3a9f0c81747002025-08-20T03:07:40ZengNature PortfolioScientific Reports2045-23222025-04-0115111410.1038/s41598-025-96774-1Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutationHaejung Kim0Goeun Park1Myoung Kyoung Kim2Young Lyun Oh3Tae Hyuk Kim4Jung Hee Shin5Soo Yeon Hahn6Department of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of MedicineBiomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical CenterDepartment of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract TERT promoter mutation is associated with poor prognosis in differentiated thyroid carcinoma, with US features varying by mutation status. However, this correlation in anaplastic thyroid carcinoma (ATC) is understudied. We investigated the association between clinicopathological characteristics and US features of ATC with TERT mutation status and prognosis. From November 1994 to May 2022, 58 ATC nodules from 58 patients were analyzed. Two radiologists retrospectively reviewed US features based on the revised K-TIRADS and ACR-TIRADS. Of all 58 ATC nodules, 32 nodules were tested for TERT promoter mutation and detected in 11. TERT promoter-mutated ATC was larger than TERT wild-type ATC (p = 0.032); however, no other differences were observed. ATC with survival period of less than 12 months were more likely to have lymph node metastasis (p = 0.012) or distant metastasis at diagnosis (p < 0.001), larger size on US (p = 0.005), and suspicion for gross extrathyroidal extension on US (p = 0.04) compared to ATC with survival period of 12 months or more. Advanced disease at diagnosis was a critical factor associated with 1-year survival in patients with ATC, whereas the TERT promoter mutation status was not.https://doi.org/10.1038/s41598-025-96774-1Thyroid cancerAnaplastic thyroid carcinomaUltrasonographyTERT promoter mutationPrognosis |
| spellingShingle | Haejung Kim Goeun Park Myoung Kyoung Kim Young Lyun Oh Tae Hyuk Kim Jung Hee Shin Soo Yeon Hahn Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation Scientific Reports Thyroid cancer Anaplastic thyroid carcinoma Ultrasonography TERT promoter mutation Prognosis |
| title | Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation |
| title_full | Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation |
| title_fullStr | Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation |
| title_full_unstemmed | Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation |
| title_short | Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation |
| title_sort | prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond tert promoter mutation |
| topic | Thyroid cancer Anaplastic thyroid carcinoma Ultrasonography TERT promoter mutation Prognosis |
| url | https://doi.org/10.1038/s41598-025-96774-1 |
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