Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune dysregulation that results in multiorgan failure; HIV and histoplasmosis are known triggers of HLH. A young patient with AIDS was found to have disseminated histoplasmosis and met criteria for HLH. Despite 10 days of t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Global Infectious Diseases |
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| Online Access: | https://journals.lww.com/10.4103/jgid.jgid_150_24 |
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| _version_ | 1850192218732625920 |
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| author | Zachary Mostel James Speed Rogers Sushrita Neogi |
| author_facet | Zachary Mostel James Speed Rogers Sushrita Neogi |
| author_sort | Zachary Mostel |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune dysregulation that results in multiorgan failure; HIV and histoplasmosis are known triggers of HLH. A young patient with AIDS was found to have disseminated histoplasmosis and met criteria for HLH. Despite 10 days of treatment with liposomal amphotericin B, she developed shock and acute respiratory distress syndrome and ultimately died. The few reported cases of HLH due to histoplasmosis in AIDS offer a variety of treatment approaches. There have been successful outcomes combining amphotericin with chemotherapies for HLH. Targeted therapies for HLH may be considered on a case-by-case basis in the setting of concurrent disseminated histoplasmosis and HIV/AIDS. |
| format | Article |
| id | doaj-art-cb9cdab0a9814d0e86d1ded1d2849382 |
| institution | OA Journals |
| issn | 0974-777X 0974-8245 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Global Infectious Diseases |
| spelling | doaj-art-cb9cdab0a9814d0e86d1ded1d28493822025-08-20T02:14:38ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X0974-82452025-01-01171636510.4103/jgid.jgid_150_24Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDSZachary MostelJames Speed RogersSushrita NeogiHemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune dysregulation that results in multiorgan failure; HIV and histoplasmosis are known triggers of HLH. A young patient with AIDS was found to have disseminated histoplasmosis and met criteria for HLH. Despite 10 days of treatment with liposomal amphotericin B, she developed shock and acute respiratory distress syndrome and ultimately died. The few reported cases of HLH due to histoplasmosis in AIDS offer a variety of treatment approaches. There have been successful outcomes combining amphotericin with chemotherapies for HLH. Targeted therapies for HLH may be considered on a case-by-case basis in the setting of concurrent disseminated histoplasmosis and HIV/AIDS.https://journals.lww.com/10.4103/jgid.jgid_150_24aidsamphotericin bhemophagocytic lymphohistiocytosishistoplasmosishiv |
| spellingShingle | Zachary Mostel James Speed Rogers Sushrita Neogi Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS Journal of Global Infectious Diseases aids amphotericin b hemophagocytic lymphohistiocytosis histoplasmosis hiv |
| title | Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS |
| title_full | Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS |
| title_fullStr | Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS |
| title_short | Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS |
| title_sort | hemophagocytic lymphohistiocytosis due to disseminated histoplasmosis in a young patient with aids |
| topic | aids amphotericin b hemophagocytic lymphohistiocytosis histoplasmosis hiv |
| url | https://journals.lww.com/10.4103/jgid.jgid_150_24 |
| work_keys_str_mv | AT zacharymostel hemophagocyticlymphohistiocytosisduetodisseminatedhistoplasmosisinayoungpatientwithaids AT jamesspeedrogers hemophagocyticlymphohistiocytosisduetodisseminatedhistoplasmosisinayoungpatientwithaids AT sushritaneogi hemophagocyticlymphohistiocytosisduetodisseminatedhistoplasmosisinayoungpatientwithaids |