The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition
Aim: To assess the Eculizumab effect on the allografted kidney function in the immediate and early postoperative period.Materials and methods: In kidney transplantation, 33 patients received Eculizumab in combination with Alemtuzumab (group 1). Other 38 patients (group 2) were enrolled for a compara...
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2017-03-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/149 |
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| author | V. A. Goryaynov M. M. Kaabak N. N. Babenko M. M. Morozova A. G. Aganesov E. N. Platova O. V. Dymova V. V. Panin |
| author_facet | V. A. Goryaynov M. M. Kaabak N. N. Babenko M. M. Morozova A. G. Aganesov E. N. Platova O. V. Dymova V. V. Panin |
| author_sort | V. A. Goryaynov |
| collection | DOAJ |
| description | Aim: To assess the Eculizumab effect on the allografted kidney function in the immediate and early postoperative period.Materials and methods: In kidney transplantation, 33 patients received Eculizumab in combination with Alemtuzumab (group 1). Other 38 patients (group 2) were enrolled for a comparative analysis. They received their induction immunosuppressive therapy with Alemtuzumab and plasmapheresis sessions. The following parameters were used for analysis: the urine output in the first 24 hours after surgery, the period of creatinine level drop to 3 mg/dL, a 24-hour protein excretion at day 30 after surgery, a glomerular filtration rate at day 30 after transplantation, histology of kidney allograft biopsy at 1 month post surgery.Results: A comparative analysis has demonstrated much lower values of 24 hour proteinuria in group 1 than in group 2. As to the glomerular filtration rate, it was 1.9 times higher in group 1 than in group 2. The period of blood creatinine subnormalization was significantly shorter in group 1. The differences were statistically significant in all studied parameters (p=0.002–0.003).Conclusion: The allografted kidney function was much better in group 1 than in group 2. Thus, the combination of Eculizumab + Alemtuzumab had a more favorable effect on the function and morphology of allografted kidneys in the immediate and early postoperative periods compared to that of Alemtuzumab + plasmapheresis combination. |
| format | Article |
| id | doaj-art-cb9bda3de18a4b4c84401451ffe86a08 |
| institution | Kabale University |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-cb9bda3de18a4b4c84401451ffe86a082025-08-20T03:56:37ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092017-03-019171110.23873/2074-0506-2017-9-1-7-11147The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney conditionV. A. Goryaynov0M. M. Kaabak1N. N. Babenko2M. M. Morozova3A. G. Aganesov4E. N. Platova5O. V. Dymova6V. V. Panin7Petrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryPetrovsky National Research Centre of SurgeryAim: To assess the Eculizumab effect on the allografted kidney function in the immediate and early postoperative period.Materials and methods: In kidney transplantation, 33 patients received Eculizumab in combination with Alemtuzumab (group 1). Other 38 patients (group 2) were enrolled for a comparative analysis. They received their induction immunosuppressive therapy with Alemtuzumab and plasmapheresis sessions. The following parameters were used for analysis: the urine output in the first 24 hours after surgery, the period of creatinine level drop to 3 mg/dL, a 24-hour protein excretion at day 30 after surgery, a glomerular filtration rate at day 30 after transplantation, histology of kidney allograft biopsy at 1 month post surgery.Results: A comparative analysis has demonstrated much lower values of 24 hour proteinuria in group 1 than in group 2. As to the glomerular filtration rate, it was 1.9 times higher in group 1 than in group 2. The period of blood creatinine subnormalization was significantly shorter in group 1. The differences were statistically significant in all studied parameters (p=0.002–0.003).Conclusion: The allografted kidney function was much better in group 1 than in group 2. Thus, the combination of Eculizumab + Alemtuzumab had a more favorable effect on the function and morphology of allografted kidneys in the immediate and early postoperative periods compared to that of Alemtuzumab + plasmapheresis combination.https://www.jtransplantologiya.ru/jour/article/view/149kidney transplantationinduction immunosuppressioneculizumabalemtuzumaballografted kidney function. |
| spellingShingle | V. A. Goryaynov M. M. Kaabak N. N. Babenko M. M. Morozova A. G. Aganesov E. N. Platova O. V. Dymova V. V. Panin The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition Трансплантология (Москва) kidney transplantation induction immunosuppression eculizumab alemtuzumab allografted kidney function. |
| title | The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition |
| title_full | The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition |
| title_fullStr | The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition |
| title_full_unstemmed | The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition |
| title_short | The effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition |
| title_sort | effect of the applied induction immunosuppressive therapy protocol on the allografted kidney condition |
| topic | kidney transplantation induction immunosuppression eculizumab alemtuzumab allografted kidney function. |
| url | https://www.jtransplantologiya.ru/jour/article/view/149 |
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