Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression
ABSTRACT Activin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces BMPR‐II in pulmonary endothelial cel...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1002/pul2.70095 |
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| _version_ | 1850108823765778432 |
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| author | Benjamin J. Dunmore Nobuhiro Kikuchi Wei Li Paul D. Upton Nicholas W. Morrell |
| author_facet | Benjamin J. Dunmore Nobuhiro Kikuchi Wei Li Paul D. Upton Nicholas W. Morrell |
| author_sort | Benjamin J. Dunmore |
| collection | DOAJ |
| description | ABSTRACT Activin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces BMPR‐II in pulmonary endothelial cells. Thus, it seems unlikely that sotatercept influences BMPR‐II or PAH via this mechanism. |
| format | Article |
| id | doaj-art-cb8bce8fca0a4a3ba353bbee4a5e77db |
| institution | OA Journals |
| issn | 2045-8940 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj-art-cb8bce8fca0a4a3ba353bbee4a5e77db2025-08-20T02:38:14ZengWileyPulmonary Circulation2045-89402025-04-01152n/an/a10.1002/pul2.70095Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor ExpressionBenjamin J. Dunmore0Nobuhiro Kikuchi1Wei Li2Paul D. Upton3Nicholas W. Morrell4Victor Phillip Dahdaleh Heart and Lung Research Institute University of Cambridge Cambridge UKVictor Phillip Dahdaleh Heart and Lung Research Institute University of Cambridge Cambridge UKVictor Phillip Dahdaleh Heart and Lung Research Institute University of Cambridge Cambridge UKVictor Phillip Dahdaleh Heart and Lung Research Institute University of Cambridge Cambridge UKVictor Phillip Dahdaleh Heart and Lung Research Institute University of Cambridge Cambridge UKABSTRACT Activin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces BMPR‐II in pulmonary endothelial cells. Thus, it seems unlikely that sotatercept influences BMPR‐II or PAH via this mechanism.https://doi.org/10.1002/pul2.70095 |
| spellingShingle | Benjamin J. Dunmore Nobuhiro Kikuchi Wei Li Paul D. Upton Nicholas W. Morrell Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression Pulmonary Circulation |
| title | Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression |
| title_full | Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression |
| title_fullStr | Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression |
| title_full_unstemmed | Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression |
| title_short | Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression |
| title_sort | activin a regulates bone morphogenetic protein signaling in pulmonary endothelial cells without affecting bone morphogenetic protein type ii receptor expression |
| url | https://doi.org/10.1002/pul2.70095 |
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