PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequ...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/95 |
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| author | A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov |
| author_facet | A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov |
| author_sort | A. V. Shevchenko |
| collection | DOAJ |
| description | We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations. |
| format | Article |
| id | doaj-art-cb87d8258f68484e9eae1a024309ed8c |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-cb87d8258f68484e9eae1a024309ed8c2025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0112321922610.15789/1563-0625-2010-3-219-22693PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTIONA. V. Shevchenko0O. V. Golovanova1V. I. Konenkov2M. I. Voevoda3V. N. Maximov4Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. НовосибирскУчреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. НовосибирскУчреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. НовосибирскУчреждение Российской академии медицинских наук Научно-исследовательский институт терапии Сибирского отделения РАМН, г. НовосибирскУчреждение Российской академии медицинских наук Научно-исследовательский институт терапии Сибирского отделения РАМН, г. НовосибирскWe have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations.https://www.mimmun.ru/mimmun/article/view/95myocardial infarctionil-1β gene polymorphismconventional risk factors |
| spellingShingle | A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION Медицинская иммунология myocardial infarction il-1β gene polymorphism conventional risk factors |
| title | PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION |
| title_full | PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION |
| title_fullStr | PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION |
| title_full_unstemmed | PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION |
| title_short | PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION |
| title_sort | promoter polymorphism of il 1β gene in patients with a history of acute myocardial infarction |
| topic | myocardial infarction il-1β gene polymorphism conventional risk factors |
| url | https://www.mimmun.ru/mimmun/article/view/95 |
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