Indole-3-propionic acid promotes hepatic stellate cells inactivation

Indole-3-propionic acid promotes hepatic stellate cells inactivation

Abstract Background & aims We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis. Now, we explored the transcriptome and DNA methylome associated with serum IPA levels in human liver from...

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Main Authors: Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, Eija Pirinen, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Maija Vaittinen, Jussi Pihlajamäki
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Indole-3-propionic acid
Liver fibrosis
Hepatic stellate cells
Apoptosis
Mitochondrial metabolism
Epigenetics
Online Access:https://doi.org/10.1186/s12967-025-06266-z
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