Computational strategies for PROTAC drug discovery
Proteolysis-targeting chimeras (PROTACs), a novel targeted protein degradation technology for potential clinical drug discovery, is composed of a protein-targeting ligand covalently linked to an E3 ligase ligand. Through recruiting E3 ligase to target proteins, PROTACs elicit ubiquitination and subs...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2023-01-01
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| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0041 |
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