Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate
We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-l...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/340737 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683963340128256 |
|---|---|
| author | Talib Hussain Mahvash Ansari Nazar Muhammad Ranjha Ikram Ullah Khan Yasser Shahzad |
| author_facet | Talib Hussain Mahvash Ansari Nazar Muhammad Ranjha Ikram Ullah Khan Yasser Shahzad |
| author_sort | Talib Hussain |
| collection | DOAJ |
| description | We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-linker and initiator, respectively. Effect of acrylic acid (AA), polyvinylsulfonic acid (PVSA), and EGDMA on prepared hydrogels was investigated. All formulations showed higher swelling at high pHs and vice versa. Formulations containing higher content of AA and EGDMA show reduced swelling, but one with higher content of PVSA showed increased swelling. Hydrogel network was characterized by determining structural parameters and loaded with isosorbide mononitrate. FTIR confirmed absence of drug polymer interaction while DSC and TGA demonstrated molecular dispersion of drug in a thermally stable polymeric network. All the hydrogel formulations exhibited a pH dependent release of isosorbide mononitrate which was found to be directly proportional to pH of the medium and PVSA content and inversely proportional to the AA contents. Drug release data were fitted to various kinetics models. Results indicated that release of isosorbide mononitrate from poly(AA-co-VSA) hydrogels was non-Fickian and that the mechanism was diffusion-controlled. |
| format | Article |
| id | doaj-art-cb7ed23ee36a4b3b90e22e4637a96de7 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cb7ed23ee36a4b3b90e22e4637a96de72025-08-20T03:23:37ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/340737340737Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide MononitrateTalib Hussain0Mahvash Ansari1Nazar Muhammad Ranjha2Ikram Ullah Khan3Yasser Shahzad4Division of Pharmacy and Pharmaceutical Science, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UKFaculty of Pharmacy, Bahauddin Zakariya University, Bosan Road, Multan 68000, Punjab, PakistanFaculty of Pharmacy, Bahauddin Zakariya University, Bosan Road, Multan 68000, Punjab, PakistanCollege of Pharmacy, GC University Faisalabad, Jinnah Town, Faisalabad 38000, Punjab, PakistanDivision of Pharmacy and Pharmaceutical Science, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UKWe report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-linker and initiator, respectively. Effect of acrylic acid (AA), polyvinylsulfonic acid (PVSA), and EGDMA on prepared hydrogels was investigated. All formulations showed higher swelling at high pHs and vice versa. Formulations containing higher content of AA and EGDMA show reduced swelling, but one with higher content of PVSA showed increased swelling. Hydrogel network was characterized by determining structural parameters and loaded with isosorbide mononitrate. FTIR confirmed absence of drug polymer interaction while DSC and TGA demonstrated molecular dispersion of drug in a thermally stable polymeric network. All the hydrogel formulations exhibited a pH dependent release of isosorbide mononitrate which was found to be directly proportional to pH of the medium and PVSA content and inversely proportional to the AA contents. Drug release data were fitted to various kinetics models. Results indicated that release of isosorbide mononitrate from poly(AA-co-VSA) hydrogels was non-Fickian and that the mechanism was diffusion-controlled.http://dx.doi.org/10.1155/2013/340737 |
| spellingShingle | Talib Hussain Mahvash Ansari Nazar Muhammad Ranjha Ikram Ullah Khan Yasser Shahzad Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate The Scientific World Journal |
| title | Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate |
| title_full | Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate |
| title_fullStr | Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate |
| title_full_unstemmed | Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate |
| title_short | Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate |
| title_sort | chemically cross linked poly acrylic co vinylsulfonic acid hydrogel for the delivery of isosorbide mononitrate |
| url | http://dx.doi.org/10.1155/2013/340737 |
| work_keys_str_mv | AT talibhussain chemicallycrosslinkedpolyacryliccovinylsulfonicacidhydrogelforthedeliveryofisosorbidemononitrate AT mahvashansari chemicallycrosslinkedpolyacryliccovinylsulfonicacidhydrogelforthedeliveryofisosorbidemononitrate AT nazarmuhammadranjha chemicallycrosslinkedpolyacryliccovinylsulfonicacidhydrogelforthedeliveryofisosorbidemononitrate AT ikramullahkhan chemicallycrosslinkedpolyacryliccovinylsulfonicacidhydrogelforthedeliveryofisosorbidemononitrate AT yassershahzad chemicallycrosslinkedpolyacryliccovinylsulfonicacidhydrogelforthedeliveryofisosorbidemononitrate |