The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells
The proliferation of vascular smooth muscle cells (VSMCs) is a key pathogenic characteristic of vascular remodeling diseases. The signal transducers and activators of transcription-3 (STAT3) signaling pathway is crucial for VSMCs growth, and its role in cytokine-induced VSMCs proliferation, calcific...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-11-01
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| Series: | Journal of Holistic Integrative Pharmacy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368823001127 |
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| _version_ | 1850194045955997696 |
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| author | Shuai Li Chan Liu |
| author_facet | Shuai Li Chan Liu |
| author_sort | Shuai Li |
| collection | DOAJ |
| description | The proliferation of vascular smooth muscle cells (VSMCs) is a key pathogenic characteristic of vascular remodeling diseases. The signal transducers and activators of transcription-3 (STAT3) signaling pathway is crucial for VSMCs growth, and its role in cytokine-induced VSMCs proliferation, calcification, and phenotypic switching is essential for developing new treatment targets. VSMCs can transform from contractile to synthetic phenotypes in response to stimuli, such as mechanical forces, growth factors, pro-inflammatory cytokines, and vascular injury. Understanding the mechanism of VSMCs proliferation triggered by the STAT3 pathway is important for identifying potential therapeutic targets for vascular remodeling diseases. |
| format | Article |
| id | doaj-art-cb7c0bb684ed41cc8791fab16f89c574 |
| institution | OA Journals |
| issn | 2707-3688 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-cb7c0bb684ed41cc8791fab16f89c5742025-08-20T02:14:06ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882023-11-014324124710.1016/j.jhip.2023.11.007The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cellsShuai Li0Chan Liu1Department of Pharmacy, Liuyang People's Hospital, Liuyang, 410300, ChinaCorresponding author. Liuyang People's Hospital, 452 Daowu Road, Jili District, Liuyang, Hunan, 410300, China.; Department of Pharmacy, Liuyang People's Hospital, Liuyang, 410300, ChinaThe proliferation of vascular smooth muscle cells (VSMCs) is a key pathogenic characteristic of vascular remodeling diseases. The signal transducers and activators of transcription-3 (STAT3) signaling pathway is crucial for VSMCs growth, and its role in cytokine-induced VSMCs proliferation, calcification, and phenotypic switching is essential for developing new treatment targets. VSMCs can transform from contractile to synthetic phenotypes in response to stimuli, such as mechanical forces, growth factors, pro-inflammatory cytokines, and vascular injury. Understanding the mechanism of VSMCs proliferation triggered by the STAT3 pathway is important for identifying potential therapeutic targets for vascular remodeling diseases.http://www.sciencedirect.com/science/article/pii/S2707368823001127STAT3VSMCsProliferationCalcificationPhenotypic switching |
| spellingShingle | Shuai Li Chan Liu The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells Journal of Holistic Integrative Pharmacy STAT3 VSMCs Proliferation Calcification Phenotypic switching |
| title | The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells |
| title_full | The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells |
| title_fullStr | The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells |
| title_full_unstemmed | The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells |
| title_short | The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells |
| title_sort | critical role of signal transducers and activators of transcription 3 in the proliferation of vascular smooth muscle cells |
| topic | STAT3 VSMCs Proliferation Calcification Phenotypic switching |
| url | http://www.sciencedirect.com/science/article/pii/S2707368823001127 |
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