Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University
Laboratory animals are essential in scientific research and experimental teaching in colleges and universities. Disciplines such as life sciences, medicine, pharmacy, chemistry, and biomedical engineering heavily rely on animal experiments. The standardized barrier environmental facility for laborat...
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Editorial Office of Laboratory Animal and Comparative Medicine
2025-02-01
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| Series: | Shiyan dongwu yu bijiao yixue |
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| Online Access: | https://www.slarc.org.cn/dwyx/article/2025/1674-5817/1674-5817-2025-45-1-96.shtml |
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| _version_ | 1849340026016497664 |
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| author | HOU Dongxia TIE Zuoxiu LU Yong NAN Panpan BAO Jie |
| author_facet | HOU Dongxia TIE Zuoxiu LU Yong NAN Panpan BAO Jie |
| author_sort | HOU Dongxia |
| collection | DOAJ |
| description | Laboratory animals are essential in scientific research and experimental teaching in colleges and universities. Disciplines such as life sciences, medicine, pharmacy, chemistry, and biomedical engineering heavily rely on animal experiments. The standardized barrier environmental facility for laboratory animals provides a fundamental platform for stable, scientific, and reliable animal experiment results. Rigorous access management for such facilities is a vital safeguard for maintaining standardized operations of facilities, controlling the quality and stability of laboratory animals, mitigating pathogen contamination risks among animals and laboratory staff, and preventing biosecurity incidents such as zoonotic disease outbreaks. Taking the small-scale barrier facilities for laboratory rats and mice at Nanjing University's Xianlin Campus, operational since 2019, as an example, this study focuses on the safety access management system of these facilities. Based on five years of operational data and accumulated experience in studying and optimizing the access management system, this study, from the perspectives of management system development and the formulation and implementation of standard operating procedures, reviews five aspects of access management: personnel access, animals access, material access, equipment access, and air circulation control. Furthermore, these aspects are systematically analyzed and summarized to serve as a reference for the construction and management of the laboratory animal facilities in universities, while also contributing to scientific research, public health security, and the well-being of experimental personnel. |
| format | Article |
| id | doaj-art-cb7b6e41d4e6465b9baf600b38e67021 |
| institution | Kabale University |
| issn | 1674-5817 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj-art-cb7b6e41d4e6465b9baf600b38e670212025-08-20T03:44:00ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172025-02-014519610010.12300/j.issn.1674-5817.2024.1061674-5817（2025）01-0096-05Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing UniversityHOU Dongxia0TIE Zuoxiu1LU Yong2NAN Panpan3BAO Jie4School of Life Sciences, Nanjing University, Nanjing 210023, ChinaCollege of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, ChinaSchool of Life Sciences, Nanjing University, Nanjing 210023, ChinaLaboratory and Equipment Management Office, Nanjing University, Nanjing 210023, ChinaSchool of Life Sciences, Nanjing University, Nanjing 210023, ChinaLaboratory animals are essential in scientific research and experimental teaching in colleges and universities. Disciplines such as life sciences, medicine, pharmacy, chemistry, and biomedical engineering heavily rely on animal experiments. The standardized barrier environmental facility for laboratory animals provides a fundamental platform for stable, scientific, and reliable animal experiment results. Rigorous access management for such facilities is a vital safeguard for maintaining standardized operations of facilities, controlling the quality and stability of laboratory animals, mitigating pathogen contamination risks among animals and laboratory staff, and preventing biosecurity incidents such as zoonotic disease outbreaks. Taking the small-scale barrier facilities for laboratory rats and mice at Nanjing University's Xianlin Campus, operational since 2019, as an example, this study focuses on the safety access management system of these facilities. Based on five years of operational data and accumulated experience in studying and optimizing the access management system, this study, from the perspectives of management system development and the formulation and implementation of standard operating procedures, reviews five aspects of access management: personnel access, animals access, material access, equipment access, and air circulation control. Furthermore, these aspects are systematically analyzed and summarized to serve as a reference for the construction and management of the laboratory animal facilities in universities, while also contributing to scientific research, public health security, and the well-being of experimental personnel.https://www.slarc.org.cn/dwyx/article/2025/1674-5817/1674-5817-2025-45-1-96.shtmllaboratory animalbarrier environmental facilityaccess managementbiosafety |
| spellingShingle | HOU Dongxia TIE Zuoxiu LU Yong NAN Panpan BAO Jie Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University Shiyan dongwu yu bijiao yixue laboratory animal barrier environmental facility access management biosafety |
| title | Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University |
| title_full | Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University |
| title_fullStr | Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University |
| title_full_unstemmed | Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University |
| title_short | Exploration and Practice of Safe Access System Construction for Barrier Environment Facilities of Laboratory Animals: A Case Study on Xianlin Campus of Nanjing University |
| title_sort | exploration and practice of safe access system construction for barrier environment facilities of laboratory animals a case study on xianlin campus of nanjing university |
| topic | laboratory animal barrier environmental facility access management biosafety |
| url | https://www.slarc.org.cn/dwyx/article/2025/1674-5817/1674-5817-2025-45-1-96.shtml |
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