Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with...
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Endocrinology Research Centre
2011-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5813 |
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| author | Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov Ekaterina Mikhailovna Parfent'eva Vyacheslav Vital'evich Romanov Alexander Petrovich Nadeev |
| author_facet | Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov Ekaterina Mikhailovna Parfent'eva Vyacheslav Vital'evich Romanov Alexander Petrovich Nadeev |
| author_sort | Irina Arkad'evna Bondar' |
| collection | DOAJ |
| description | Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with macroalbuminuria) by an enzyme immunoassay. 10 healthy individuals were acted as the control group. Renal biopsy was performedin 22 patients. Deposits of type IV collagen were revealed by 11 individuals by immunohistochemistry. Results. The urinary excretion of type IV collagen increased with severety of diabetic nephropathy, correlating with the urinary albumin/creatinineratio, serum creatinine and parameters of daytime and nighttime systolic and diastolic blood pressure. Patients with excessive accumulation of typeIV collagen in the glomeruli had significantly higher level of type IV collagen in the urine. Conclusion. The determination of urinary type IV collagen can be used for early detection of renal fibrosis in patients with type 1 diabetes. |
| format | Article |
| id | doaj-art-cb78caa72c344a66a7dcc87ed9e7dbc5 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2011-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-cb78caa72c344a66a7dcc87ed9e7dbc52025-08-20T01:57:09ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782011-12-01144293110.14341/2072-0351-58135771Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitusIrina Arkad'evna Bondar'0Vadim Valer'evich Klimontov1Ekaterina Mikhailovna Parfent'eva2Vyacheslav Vital'evich Romanov3Alexander Petrovich Nadeev4Novosibirsk State Medical University, NovosibirskNovosibirsk State Medical University, NovosibirskNovosibirsk State Medical University, NovosibirskLtd. "INVITRO", NovosibirskNovosibirsk State Medical University, NovosibirskAim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with macroalbuminuria) by an enzyme immunoassay. 10 healthy individuals were acted as the control group. Renal biopsy was performedin 22 patients. Deposits of type IV collagen were revealed by 11 individuals by immunohistochemistry. Results. The urinary excretion of type IV collagen increased with severety of diabetic nephropathy, correlating with the urinary albumin/creatinineratio, serum creatinine and parameters of daytime and nighttime systolic and diastolic blood pressure. Patients with excessive accumulation of typeIV collagen in the glomeruli had significantly higher level of type IV collagen in the urine. Conclusion. The determination of urinary type IV collagen can be used for early detection of renal fibrosis in patients with type 1 diabetes.https://www.dia-endojournals.ru/jour/article/view/5813type 1 diabetes mellitusdiabetic nephropathytype iv collagen |
| spellingShingle | Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov Ekaterina Mikhailovna Parfent'eva Vyacheslav Vital'evich Romanov Alexander Petrovich Nadeev Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus Сахарный диабет type 1 diabetes mellitus diabetic nephropathy type iv collagen |
| title | Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus |
| title_full | Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus |
| title_fullStr | Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus |
| title_full_unstemmed | Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus |
| title_short | Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus |
| title_sort | urinary excretion of type iv collagen as an early marker of renal fibrosis in patients with diabetes mellitus |
| topic | type 1 diabetes mellitus diabetic nephropathy type iv collagen |
| url | https://www.dia-endojournals.ru/jour/article/view/5813 |
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