Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques.
<h4>Introduction</h4>Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore diffic...
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0145022 |
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| author | Claudia Geue Olivia Wu Yiqiao Xin Robert Heggie Sharon Hutchinson Natasha K Martin Elisabeth Fenwick David Goldberg Consortium ECDC |
| author_facet | Claudia Geue Olivia Wu Yiqiao Xin Robert Heggie Sharon Hutchinson Natasha K Martin Elisabeth Fenwick David Goldberg Consortium ECDC |
| author_sort | Claudia Geue |
| collection | DOAJ |
| description | <h4>Introduction</h4>Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost-effectiveness results between studies. This systematic review aims to summarise and critically assess existing economic models for HBV and HCV in order to identify the main methodological differences in modelling approaches.<h4>Methods</h4>A structured search strategy was developed and a systematic review carried out. A critical assessment of the decision-analytic models was carried out according to the guidelines and framework developed for assessment of decision-analytic models in Health Technology Assessment of health care interventions.<h4>Results</h4>The overall approach to analysing the cost-effectiveness of screening strategies was found to be broadly consistent for HBV and HCV. However, modelling parameters and related structure differed between models, producing different results. More recent publications performed better against a performance matrix, evaluating model components and methodology.<h4>Conclusion</h4>When assessing screening strategies for HBV and HCV infection, the focus should be on more recent studies, which applied the latest treatment regimes, test methods and had better and more complete data on which to base their models. In addition to parameter selection and associated assumptions, careful consideration of dynamic versus static modelling is recommended. Future research may want to focus on these methodological issues. In addition, the ability to evaluate screening strategies for multiple infectious diseases, (HCV and HIV at the same time) might prove important for decision makers. |
| format | Article |
| id | doaj-art-cb76e055e6204a37ab95b99e1cd545b5 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-cb76e055e6204a37ab95b99e1cd545b52025-08-20T03:50:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014502210.1371/journal.pone.0145022Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques.Claudia GeueOlivia WuYiqiao XinRobert HeggieSharon HutchinsonNatasha K MartinElisabeth FenwickDavid GoldbergConsortiumECDC<h4>Introduction</h4>Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost-effectiveness results between studies. This systematic review aims to summarise and critically assess existing economic models for HBV and HCV in order to identify the main methodological differences in modelling approaches.<h4>Methods</h4>A structured search strategy was developed and a systematic review carried out. A critical assessment of the decision-analytic models was carried out according to the guidelines and framework developed for assessment of decision-analytic models in Health Technology Assessment of health care interventions.<h4>Results</h4>The overall approach to analysing the cost-effectiveness of screening strategies was found to be broadly consistent for HBV and HCV. However, modelling parameters and related structure differed between models, producing different results. More recent publications performed better against a performance matrix, evaluating model components and methodology.<h4>Conclusion</h4>When assessing screening strategies for HBV and HCV infection, the focus should be on more recent studies, which applied the latest treatment regimes, test methods and had better and more complete data on which to base their models. In addition to parameter selection and associated assumptions, careful consideration of dynamic versus static modelling is recommended. Future research may want to focus on these methodological issues. In addition, the ability to evaluate screening strategies for multiple infectious diseases, (HCV and HIV at the same time) might prove important for decision makers.https://doi.org/10.1371/journal.pone.0145022 |
| spellingShingle | Claudia Geue Olivia Wu Yiqiao Xin Robert Heggie Sharon Hutchinson Natasha K Martin Elisabeth Fenwick David Goldberg Consortium ECDC Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques. PLoS ONE |
| title | Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques. |
| title_full | Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques. |
| title_fullStr | Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques. |
| title_full_unstemmed | Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques. |
| title_short | Cost-Effectiveness of HBV and HCV Screening Strategies--A Systematic Review of Existing Modelling Techniques. |
| title_sort | cost effectiveness of hbv and hcv screening strategies a systematic review of existing modelling techniques |
| url | https://doi.org/10.1371/journal.pone.0145022 |
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