Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study
Conclusions: The study screened five potential biomarker genes in CD patients using a bioinformatics approach and Mendelian randomization study. Our results provided insights into CXCL1, LCN2, NOS2, S100A8, and DUOX2 in CD and suggested that CXCL1 may potentially be the optimal biomarker that could...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/grp/8194480 |
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| _version_ | 1849320201726722048 |
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| author | Cong Hu Shuxiong Nong Chenang Liu Yongfeng Chen Chilin Liao Meng Wu |
| author_facet | Cong Hu Shuxiong Nong Chenang Liu Yongfeng Chen Chilin Liao Meng Wu |
| author_sort | Cong Hu |
| collection | DOAJ |
| description | Conclusions: The study screened five potential biomarker genes in CD patients using a bioinformatics approach and Mendelian randomization study. Our results provided insights into CXCL1, LCN2, NOS2, S100A8, and DUOX2 in CD and suggested that CXCL1 may potentially be the optimal biomarker that could be a relatively easy path to clinical translation. |
| format | Article |
| id | doaj-art-cb7359f2dad643b7a5cc6fc5f4b8e0b9 |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-cb7359f2dad643b7a5cc6fc5f4b8e0b92025-08-20T03:50:11ZengWileyGastroenterology Research and Practice1687-630X2025-01-01202510.1155/grp/8194480Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization StudyCong Hu0Shuxiong Nong1Chenang Liu2Yongfeng Chen3Chilin Liao4Meng Wu5Department of UltrasoundDepartment of CardiologyTeaching OfficeSocial Medical Development DepartmentDepartment of CardiologyDepartment of UltrasoundConclusions: The study screened five potential biomarker genes in CD patients using a bioinformatics approach and Mendelian randomization study. Our results provided insights into CXCL1, LCN2, NOS2, S100A8, and DUOX2 in CD and suggested that CXCL1 may potentially be the optimal biomarker that could be a relatively easy path to clinical translation.http://dx.doi.org/10.1155/grp/8194480 |
| spellingShingle | Cong Hu Shuxiong Nong Chenang Liu Yongfeng Chen Chilin Liao Meng Wu Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study Gastroenterology Research and Practice |
| title | Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study |
| title_full | Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study |
| title_fullStr | Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study |
| title_full_unstemmed | Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study |
| title_short | Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two-Sample Mendelian Randomization Study |
| title_sort | validation of biomarkers and immunotherapy with crohn s disease using wgcna and two sample mendelian randomization study |
| url | http://dx.doi.org/10.1155/grp/8194480 |
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