Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis and is responsible for most Leishmania-associated deaths. VL represents a serious public health problem that affects many countries. The immune response in leishmaniasis is very complex and is poorly understood. The Th1 versus Th2...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/650874 |
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| author | Rafael Paletta-Silva José Roberto Meyer-Fernandes |
| author_facet | Rafael Paletta-Silva José Roberto Meyer-Fernandes |
| author_sort | Rafael Paletta-Silva |
| collection | DOAJ |
| description | Visceral leishmaniasis (VL) is the most severe form of leishmaniasis and is responsible for most Leishmania-associated deaths. VL represents a serious public health problem that affects many countries. The immune response in leishmaniasis is very complex and is poorly understood. The Th1 versus Th2 paradigm does not appear to be so clear in visceral leishmaniasis, suggesting that other immunosuppressive or immune-evasion mechanisms contribute to the pathogenesis of VL. It has been demonstrated that generation of adenosine, a potent endogenous immunosuppressant, by extracellular enzymes capable to hydrolyze adenosine tri-nucleotide (ATP) at the site of infection, can lead to immune impairment and contribute to leishmaniasis progression. In this regard, this paper discusses the unique features in VL immunopathogenesis, including a possible role for ectonucleotidases in leishmaniasis. |
| format | Article |
| id | doaj-art-cb7246cc0f7245a5a543fc2115804af4 |
| institution | DOAJ |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-cb7246cc0f7245a5a543fc2115804af42025-08-20T03:23:37ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/650874650874Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of EctonucleotidasesRafael Paletta-Silva0José Roberto Meyer-Fernandes1Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilVisceral leishmaniasis (VL) is the most severe form of leishmaniasis and is responsible for most Leishmania-associated deaths. VL represents a serious public health problem that affects many countries. The immune response in leishmaniasis is very complex and is poorly understood. The Th1 versus Th2 paradigm does not appear to be so clear in visceral leishmaniasis, suggesting that other immunosuppressive or immune-evasion mechanisms contribute to the pathogenesis of VL. It has been demonstrated that generation of adenosine, a potent endogenous immunosuppressant, by extracellular enzymes capable to hydrolyze adenosine tri-nucleotide (ATP) at the site of infection, can lead to immune impairment and contribute to leishmaniasis progression. In this regard, this paper discusses the unique features in VL immunopathogenesis, including a possible role for ectonucleotidases in leishmaniasis.http://dx.doi.org/10.1155/2012/650874 |
| spellingShingle | Rafael Paletta-Silva José Roberto Meyer-Fernandes Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases Journal of Tropical Medicine |
| title | Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases |
| title_full | Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases |
| title_fullStr | Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases |
| title_full_unstemmed | Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases |
| title_short | Adenosine and Immune Imbalance in Visceral Leishmaniasis: The Possible Role of Ectonucleotidases |
| title_sort | adenosine and immune imbalance in visceral leishmaniasis the possible role of ectonucleotidases |
| url | http://dx.doi.org/10.1155/2012/650874 |
| work_keys_str_mv | AT rafaelpalettasilva adenosineandimmuneimbalanceinvisceralleishmaniasisthepossibleroleofectonucleotidases AT joserobertomeyerfernandes adenosineandimmuneimbalanceinvisceralleishmaniasisthepossibleroleofectonucleotidases |