Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation
Roger Zaldivar,1,* Roberto Zaldivar,1,* Arthur B Cummings,2,* Brendan K Cummings,2,* Erik LJG Mertens,3,* Robert Edward Ang,4,* Lucia Irupé Zarate Piscopo,1,5,* Gabriel Quintero,1,5,* Alejandro Cerviño6,&...
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Dove Medical Press
2025-06-01
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| author | Zaldivar R Zaldivar R Cummings AB Cummings BK Mertens EL Ang RE Zarate Piscopo LI Quintero G Cerviño A |
| author_facet | Zaldivar R Zaldivar R Cummings AB Cummings BK Mertens EL Ang RE Zarate Piscopo LI Quintero G Cerviño A |
| author_sort | Zaldivar R |
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| description | Roger Zaldivar,1,&ast; Roberto Zaldivar,1,&ast; Arthur B Cummings,2,&ast; Brendan K Cummings,2,&ast; Erik LJG Mertens,3,&ast; Robert Edward Ang,4,&ast; Lucia Irupé Zarate Piscopo,1,5,&ast; Gabriel Quintero,1,5,&ast; Alejandro Cerviño6,&ast; 1Department of Refractive & Cataract Surgery, Instituto Zaldivar, Mendoza, Argentina; 2Department of Cataract & Refractive Surgery, Wellington Eye Clinic, Dublin, Ireland; 3Department of Ophthalmology, Medipolis Medical Research Institute, Antwerp, Belgium; 4Department of Cornea & Refractive Surgery, Asian Eye Institute, Manila, Phillipines; 5Department of Bioengineering, University of Mendoza, Mendoza, Argentina; 6Department of Optics & Optometry & Vision Sciences, University of Valencia, Valencia, Spain&ast;These authors contributed equally to this workCorrespondence: Roger Zaldivar, Instituto Zaldivar, Av. Emilio Civit 701, Mendoza, Argentina, Email zaldivar@zaldivar.comIntroduction: Phakic intraocular lenses are widely used for refractive error correction, with the EVO ICL delivering excellent visual outcomes. Achieving an optimal postoperative vault is critical to minimize complications. The purpose of this study was to evaluate the predictive accuracy of an AI-based tool that integrates high-resolution ultrasound biomicroscopy (UBM) imaging with biometric data, for estimating postoperative vault in myopic patients.Settings: The study was performed at four centers: Instituto Zaldivar (Argentina), Wellington Eye Clinic (Ireland), Medipolis Eye Center (Belgium), and Asian Eye Institute (Philippines).Methods: In this retrospective, multicenter study, 347 eyes from 228 myopic patients (mean age 31.3 ± 7.7 years) underwent ICL implantation. Preoperative biometric parameters and UBM imaging were utilized to generate vault predictions using the AI-based tool. Predicted vault values were compared with clinical measurements obtained at 1 day and 1 month postoperatively. Statistical analyses, including Spearman correlation and multivariable linear regression, were conducted to assess the agreement between predicted and measured vaults and to identify significant predictive factors.Results: At 1 day postoperatively, the mean clinical vault was 520.97 ± 178.73 μm versus a predicted vault of 508.16 ± 163.00 μm, with a mean signed difference of − 12.81 μm (r²=0.621, p< 0.001). Subgroup analyses across the four centers demonstrated stable predictions, with no significant inter-center differences in either clinical or predicted vault measurements (p> 0.05). Multivariable regression identified ARise and spherical power as significant predictors of vault discrepancy, with uniform effects across diverse populations.Conclusion: The ICLGuru™ reliably predicts postoperative vault with clinically acceptable accuracy. These findings underscore the generalizability and reliable performance of the AI-based tool across varied clinical settings. Its integration into preoperative planning may enhance ICL sizing and reduce complications in myopic patients.Plain Language Summary: Phakic intraocular Collamer lenses (ICLs) are special lenses implanted in the eye to correct vision problems like nearsightedness. Choosing the right size is crucial to ensure the lens fits well and does not cause complications. Doctors currently use different methods to estimate the best lens size, but these are not always perfect.This study tested a new artificial intelligence (AI) tool that predicts how much space (or “vault”) will be left between the implanted lens and the eye’s natural structures after surgery. The aim is to know if this tool could accurately estimate the vault before surgery, helping doctors choose the right lens size.To find out, 347 eyes from 228 patients who had ICL surgery in four different eye clinics around the world were analyzed. The AI tool used high-resolution ultrasound images and biometric data (measurements of the eye) to predict the vault. These predictions were then compared with actual vault measurements taken after surgery.The results showed that the AI-based tool was highly accurate, with only a small difference between predicted and actual vault values. The tool worked well across different patient groups and clinic locations. The study also identified factors, such as the shape of the eye, that slightly affected prediction accuracy.These findings suggest that AI can help eye surgeons make better decisions about lens sizing, potentially reducing the risk of complications and improving surgical outcomes for patients.Keywords: phakic intraocular lens, implantable collamer lens, lens size, vault, artificial intelligence |
| format | Article |
| id | doaj-art-cb71ff7a21f94ac0ba4a4e171b4159a6 |
| institution | Kabale University |
| issn | 1177-5483 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj-art-cb71ff7a21f94ac0ba4a4e171b4159a62025-08-20T03:32:36ZengDove Medical PressClinical Ophthalmology1177-54832025-06-01Volume 19Issue 119451956104122Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens ImplantationZaldivar R0Zaldivar R1Cummings AB2Cummings BK3Mertens EL4Ang RE5Zarate Piscopo LI6Quintero G7Cerviño A8Cataract and Refractive SurgeryRefractiveCataract & RefractiveOphthalmologyOphthalmologyCornea and Refractive SurgeryBioengineeringRDOptics & Optometry & Vision SciencesRoger Zaldivar,1,&ast; Roberto Zaldivar,1,&ast; Arthur B Cummings,2,&ast; Brendan K Cummings,2,&ast; Erik LJG Mertens,3,&ast; Robert Edward Ang,4,&ast; Lucia Irupé Zarate Piscopo,1,5,&ast; Gabriel Quintero,1,5,&ast; Alejandro Cerviño6,&ast; 1Department of Refractive & Cataract Surgery, Instituto Zaldivar, Mendoza, Argentina; 2Department of Cataract & Refractive Surgery, Wellington Eye Clinic, Dublin, Ireland; 3Department of Ophthalmology, Medipolis Medical Research Institute, Antwerp, Belgium; 4Department of Cornea & Refractive Surgery, Asian Eye Institute, Manila, Phillipines; 5Department of Bioengineering, University of Mendoza, Mendoza, Argentina; 6Department of Optics & Optometry & Vision Sciences, University of Valencia, Valencia, Spain&ast;These authors contributed equally to this workCorrespondence: Roger Zaldivar, Instituto Zaldivar, Av. Emilio Civit 701, Mendoza, Argentina, Email zaldivar@zaldivar.comIntroduction: Phakic intraocular lenses are widely used for refractive error correction, with the EVO ICL delivering excellent visual outcomes. Achieving an optimal postoperative vault is critical to minimize complications. The purpose of this study was to evaluate the predictive accuracy of an AI-based tool that integrates high-resolution ultrasound biomicroscopy (UBM) imaging with biometric data, for estimating postoperative vault in myopic patients.Settings: The study was performed at four centers: Instituto Zaldivar (Argentina), Wellington Eye Clinic (Ireland), Medipolis Eye Center (Belgium), and Asian Eye Institute (Philippines).Methods: In this retrospective, multicenter study, 347 eyes from 228 myopic patients (mean age 31.3 ± 7.7 years) underwent ICL implantation. Preoperative biometric parameters and UBM imaging were utilized to generate vault predictions using the AI-based tool. Predicted vault values were compared with clinical measurements obtained at 1 day and 1 month postoperatively. Statistical analyses, including Spearman correlation and multivariable linear regression, were conducted to assess the agreement between predicted and measured vaults and to identify significant predictive factors.Results: At 1 day postoperatively, the mean clinical vault was 520.97 ± 178.73 μm versus a predicted vault of 508.16 ± 163.00 μm, with a mean signed difference of − 12.81 μm (r²=0.621, p< 0.001). Subgroup analyses across the four centers demonstrated stable predictions, with no significant inter-center differences in either clinical or predicted vault measurements (p> 0.05). Multivariable regression identified ARise and spherical power as significant predictors of vault discrepancy, with uniform effects across diverse populations.Conclusion: The ICLGuru™ reliably predicts postoperative vault with clinically acceptable accuracy. These findings underscore the generalizability and reliable performance of the AI-based tool across varied clinical settings. Its integration into preoperative planning may enhance ICL sizing and reduce complications in myopic patients.Plain Language Summary: Phakic intraocular Collamer lenses (ICLs) are special lenses implanted in the eye to correct vision problems like nearsightedness. Choosing the right size is crucial to ensure the lens fits well and does not cause complications. Doctors currently use different methods to estimate the best lens size, but these are not always perfect.This study tested a new artificial intelligence (AI) tool that predicts how much space (or “vault”) will be left between the implanted lens and the eye’s natural structures after surgery. The aim is to know if this tool could accurately estimate the vault before surgery, helping doctors choose the right lens size.To find out, 347 eyes from 228 patients who had ICL surgery in four different eye clinics around the world were analyzed. The AI tool used high-resolution ultrasound images and biometric data (measurements of the eye) to predict the vault. These predictions were then compared with actual vault measurements taken after surgery.The results showed that the AI-based tool was highly accurate, with only a small difference between predicted and actual vault values. The tool worked well across different patient groups and clinic locations. The study also identified factors, such as the shape of the eye, that slightly affected prediction accuracy.These findings suggest that AI can help eye surgeons make better decisions about lens sizing, potentially reducing the risk of complications and improving surgical outcomes for patients.Keywords: phakic intraocular lens, implantable collamer lens, lens size, vault, artificial intelligencehttps://www.dovepress.com/evaluating-the-predictive-accuracy-of-an-ai-based-tool-for-postoperati-peer-reviewed-fulltext-article-OPTHPhakic intraocular lensImplantable collamer lensLens sizeVaultArtificial intelligence |
| spellingShingle | Zaldivar R Zaldivar R Cummings AB Cummings BK Mertens EL Ang RE Zarate Piscopo LI Quintero G Cerviño A Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation Clinical Ophthalmology Phakic intraocular lens Implantable collamer lens Lens size Vault Artificial intelligence |
| title | Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation |
| title_full | Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation |
| title_fullStr | Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation |
| title_full_unstemmed | Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation |
| title_short | Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation |
| title_sort | evaluating the predictive accuracy of an ai based tool for postoperative vault estimation in phakic intraocular lens implantation |
| topic | Phakic intraocular lens Implantable collamer lens Lens size Vault Artificial intelligence |
| url | https://www.dovepress.com/evaluating-the-predictive-accuracy-of-an-ai-based-tool-for-postoperati-peer-reviewed-fulltext-article-OPTH |
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