Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers

Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers

Natural killer (NK) cells are key players in human innate immunity. Cell engager antibody formats that recruit and activate NK cells more effectively have emerged as a promising immunotherapy approach to target cancer cells through more effective antibody-dependent cell-mediated cytotoxicity (ADCC)....

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Bibliographic Details
Main Authors: Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods, Xiaomin Fan
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
ADCC
bispecific antibodies
CD16a
engager
Fc binding
immunotherapy
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2381261
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