Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

Abstract In eukaryotic cells, splicing occurs predominantly co-transcriptionally, enhancing splicing efficiency and fidelity while introducing an additional layer of regulation over gene expression. RNA polymerase II (Pol II) facilitates co-transcriptional splicing by recruiting the U1 small nuclear...

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Main Authors: Luojia Zhang, Christopher Batters, Shintaro Aibara, Yuliya Gordiyenko, Kristina Žumer, Jana Schmitzová, Kerstin Maier, Patrick Cramer, Suyang Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60979-9
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