State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization
Hepatitis C virus (HCV) still represents a major public health threat, with a dramatic burden from both epidemiological and clinical points of view. New generation of direct-acting antiviral agents (DAAs) has been recently introduced in clinical practice promising to cure HCV and to overcome the iss...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1412840 |
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| _version_ | 1832566710159278080 |
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| author | Cecilia Trucchi Andrea Orsi Cristiano Alicino Laura Sticchi Giancarlo Icardi Filippo Ansaldi |
| author_facet | Cecilia Trucchi Andrea Orsi Cristiano Alicino Laura Sticchi Giancarlo Icardi Filippo Ansaldi |
| author_sort | Cecilia Trucchi |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) still represents a major public health threat, with a dramatic burden from both epidemiological and clinical points of view. New generation of direct-acting antiviral agents (DAAs) has been recently introduced in clinical practice promising to cure HCV and to overcome the issues related to the interferon-based therapies. However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide. Moreover, these treatments remain poorly accessible, particularly in low-income countries. Finally, effective screening strategy is crucial to early identifying and treating all HCV chronically infected patients. For all these reasons, even though new drugs may contribute to impacting HCV spread worldwide a preventive HCV vaccine remains a cornerstone in the road to significantly reduce the HCV spread globally, with the ultimate goal of its eradication. Advances in molecular vaccinology, together with a strong financial, political, and societal support, will enable reaching this fundamental success in the coming years. In this comprehensive review, the state of the art about these major topics in the fight against HCV and the future of research in these fields are discussed. |
| format | Article |
| id | doaj-art-cb68db16034c426fb0950b33dbc515a2 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cb68db16034c426fb0950b33dbc515a22025-02-03T01:03:33ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/14128401412840State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and ImmunizationCecilia Trucchi0Andrea Orsi1Cristiano Alicino2Laura Sticchi3Giancarlo Icardi4Filippo Ansaldi5Department of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyHepatitis C virus (HCV) still represents a major public health threat, with a dramatic burden from both epidemiological and clinical points of view. New generation of direct-acting antiviral agents (DAAs) has been recently introduced in clinical practice promising to cure HCV and to overcome the issues related to the interferon-based therapies. However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide. Moreover, these treatments remain poorly accessible, particularly in low-income countries. Finally, effective screening strategy is crucial to early identifying and treating all HCV chronically infected patients. For all these reasons, even though new drugs may contribute to impacting HCV spread worldwide a preventive HCV vaccine remains a cornerstone in the road to significantly reduce the HCV spread globally, with the ultimate goal of its eradication. Advances in molecular vaccinology, together with a strong financial, political, and societal support, will enable reaching this fundamental success in the coming years. In this comprehensive review, the state of the art about these major topics in the fight against HCV and the future of research in these fields are discussed.http://dx.doi.org/10.1155/2016/1412840 |
| spellingShingle | Cecilia Trucchi Andrea Orsi Cristiano Alicino Laura Sticchi Giancarlo Icardi Filippo Ansaldi State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization Journal of Immunology Research |
| title | State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization |
| title_full | State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization |
| title_fullStr | State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization |
| title_full_unstemmed | State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization |
| title_short | State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization |
| title_sort | state of the art unresolved issues and future research directions in the fight against hepatitis c virus perspectives for screening diagnostics of resistances and immunization |
| url | http://dx.doi.org/10.1155/2016/1412840 |
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