Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study
Objectives Triglyceride glucose (TyG) represents a consistent surrogate biomarker and index of insulin resistance (IR), IR has also been linked to skeletal muscle mass loss (SMM-L). Here, we evaluated the association between SMM-L and the TyG index (TyGi).Design An analytical cross-sectional study.S...
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BMJ Publishing Group
2024-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/1/e077484.full |
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| author | Zhenzhen Li Jirong Yue Ting Bao Xiang Tong Yao Ma |
| author_facet | Zhenzhen Li Jirong Yue Ting Bao Xiang Tong Yao Ma |
| author_sort | Zhenzhen Li |
| collection | DOAJ |
| description | Objectives Triglyceride glucose (TyG) represents a consistent surrogate biomarker and index of insulin resistance (IR), IR has also been linked to skeletal muscle mass loss (SMM-L). Here, we evaluated the association between SMM-L and the TyG index (TyGi).Design An analytical cross-sectional study.Setting Tertiary care hospitals.Participants 36 275 participants who underwent health checks between 1 January 2013 and 31 December 2020.Primary and secondary outcome measures A bioelectrical impedance analysis was used to assess the body composition, SMM-L was defined as low ASMI (total limb lean mass/height2) and TyGi was calculated as ln(triglycerides (mg/dL)×fasting blood glucose (mg/dL)/2).Results A total of 36 275 subjects were included in the study, of which 58.46% were male, with a mean age of 43.74±12.33 years. The prevalence of low skeletal muscle mass (SMM) was 17.7% and the mean TyGi was 8.56±0.64. TyGi was found to be significantly correlated with low SMM in all subjects (OR 1.87, 95% CI 1.75 to 2.00, p<0.001), with higher correlations seen in younger subjects (OR 1.97, 95% CI 1.77 to 2.20, p<0.001), and remaining significant in middle age (OR 1.95, 95% CI 1.77 to 2.14, p<0.001), old age (OR 1.73, 95% CI 1.38 to 1.16, p<0.001), men (OR 1.60, 95% CI 1.46 to 1.76, p<0.001) and women (OR 2.59, 95% CI 2.39 to 2.87, p<0.001).Conclusions These data demonstrated a significant independent interaction between TyGi and low SMM in all subjects regardless of sex and age subgroups in the general population. |
| format | Article |
| id | doaj-art-cb61ae09caa14426990ece8f89d4b45e |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-cb61ae09caa14426990ece8f89d4b45e2025-08-20T02:13:26ZengBMJ Publishing GroupBMJ Open2044-60552024-01-0114110.1136/bmjopen-2023-077484Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional studyZhenzhen Li0Jirong Yue1Ting Bao2Xiang Tong3Yao Ma4Health Management Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaHealth Management Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ophthalmology, Peking University People`s Hospital, Beijing, ChinaObjectives Triglyceride glucose (TyG) represents a consistent surrogate biomarker and index of insulin resistance (IR), IR has also been linked to skeletal muscle mass loss (SMM-L). Here, we evaluated the association between SMM-L and the TyG index (TyGi).Design An analytical cross-sectional study.Setting Tertiary care hospitals.Participants 36 275 participants who underwent health checks between 1 January 2013 and 31 December 2020.Primary and secondary outcome measures A bioelectrical impedance analysis was used to assess the body composition, SMM-L was defined as low ASMI (total limb lean mass/height2) and TyGi was calculated as ln(triglycerides (mg/dL)×fasting blood glucose (mg/dL)/2).Results A total of 36 275 subjects were included in the study, of which 58.46% were male, with a mean age of 43.74±12.33 years. The prevalence of low skeletal muscle mass (SMM) was 17.7% and the mean TyGi was 8.56±0.64. TyGi was found to be significantly correlated with low SMM in all subjects (OR 1.87, 95% CI 1.75 to 2.00, p<0.001), with higher correlations seen in younger subjects (OR 1.97, 95% CI 1.77 to 2.20, p<0.001), and remaining significant in middle age (OR 1.95, 95% CI 1.77 to 2.14, p<0.001), old age (OR 1.73, 95% CI 1.38 to 1.16, p<0.001), men (OR 1.60, 95% CI 1.46 to 1.76, p<0.001) and women (OR 2.59, 95% CI 2.39 to 2.87, p<0.001).Conclusions These data demonstrated a significant independent interaction between TyGi and low SMM in all subjects regardless of sex and age subgroups in the general population.https://bmjopen.bmj.com/content/14/1/e077484.full |
| spellingShingle | Zhenzhen Li Jirong Yue Ting Bao Xiang Tong Yao Ma Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study BMJ Open |
| title | Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study |
| title_full | Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study |
| title_fullStr | Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study |
| title_full_unstemmed | Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study |
| title_short | Association between the triglyceride glucose index and low skeletal muscle mass: a cross-sectional study |
| title_sort | association between the triglyceride glucose index and low skeletal muscle mass a cross sectional study |
| url | https://bmjopen.bmj.com/content/14/1/e077484.full |
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