Fighting RNA viruses with a gold nanoparticle Cas13d gene-editing armor

Fighting RNA viruses with a gold nanoparticle Cas13d gene-editing armor

A novel Cas13d-based gene-editing approach has been developed to target viral RNAs in infected cells, reducing the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Zika virus (ZIKV) by up to 90% compared with controls. Despite its potential, the use of Cas13d as an ant...

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Bibliographic Details
Main Authors: Alessandro De Carli, Domenico Favaro, Carolina Filipponi, Fabio Filippini, Rossella Fonnesu, Erika Plicanti, Silvia Nottoli, Piotr Barski, Agnieszka Lindstaedt, Dariusz Witt, Alessandra Falleni, Giada Frenzilli, Ana Alcalá-Lalinde, Elena Herrera-Carrillo, Vittoria Raffa, Giulia Freer, Mauro Pistello, Michele Lai
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
SARS-CoV-2
Zika virus
Cas13d
gold nanoparticles
Au_NPs Cas13d
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125000940
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