Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats
Abstract Background Rottlerin is a natural polyphenolic compound obtained from dried ripe fruits of Mallotus philippinensis and is primarily used as a PKCδ inhibitor. The effectiveness of rottlerin was checked in the endotoxin-induced glaucoma models, focusing on its impact on intraocular pressure,...
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SpringerOpen
2025-04-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-025-00798-3 |
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| author | Nidhi Kumari Ashmita Das Nirdesh Kumar Geeta Singh Urvashi Jain Amrita Singh Surendra H. Bodakhe |
| author_facet | Nidhi Kumari Ashmita Das Nirdesh Kumar Geeta Singh Urvashi Jain Amrita Singh Surendra H. Bodakhe |
| author_sort | Nidhi Kumari |
| collection | DOAJ |
| description | Abstract Background Rottlerin is a natural polyphenolic compound obtained from dried ripe fruits of Mallotus philippinensis and is primarily used as a PKCδ inhibitor. The effectiveness of rottlerin was checked in the endotoxin-induced glaucoma models, focusing on its impact on intraocular pressure, inflammation, and optic nerve protection. For this study, both pure and extracted rottlerin were used. Extracted rottlerin was characterised by determining its melting point, conducting gas chromatography-mass spectrometry analysis, Nuclear magnetic resonance analysis, and measuring its wavelength and retardation factor. The acute toxicity study was carried out using Organization for Economic Co-operation and development guideline 405 (acute eye irritation test). Result Pure and extracted rottlerin showed decreased intraocular pressure and reduced inflammation, lenticular opacity, and retinal damage. These results are attributed to an increase in antioxidant levels, maintenance of lipid peroxidation, enzyme level (Na+ ATPase, K+ ATPase), ionic balance (Na+, K+), and a decrease in the level of nitric oxide. Conclusion Rottlerin (pure) as well as rottlerin (extracted) has demonstrated potential in managing uveitic glaucoma. Its multifaceted mechanisms not only target inflammation and oxidative stress but also promote tissue regeneration and slow disease progression. This makes rottlerin a promising candidate for further clinical research as a potential treatment for uveitic glaucoma. |
| format | Article |
| id | doaj-art-cb5f9b74882e4b0f84c580f511efbfed |
| institution | DOAJ |
| issn | 2314-7253 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj-art-cb5f9b74882e4b0f84c580f511efbfed2025-08-20T03:10:14ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532025-04-0111111310.1186/s43094-025-00798-3Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in ratsNidhi Kumari0Ashmita Das1Nirdesh Kumar2Geeta Singh3Urvashi Jain4Amrita Singh5Surendra H. Bodakhe6Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University)Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University)Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University)Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University)Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University)National Institute of Pharmaceutical Education and ResearchDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University)Abstract Background Rottlerin is a natural polyphenolic compound obtained from dried ripe fruits of Mallotus philippinensis and is primarily used as a PKCδ inhibitor. The effectiveness of rottlerin was checked in the endotoxin-induced glaucoma models, focusing on its impact on intraocular pressure, inflammation, and optic nerve protection. For this study, both pure and extracted rottlerin were used. Extracted rottlerin was characterised by determining its melting point, conducting gas chromatography-mass spectrometry analysis, Nuclear magnetic resonance analysis, and measuring its wavelength and retardation factor. The acute toxicity study was carried out using Organization for Economic Co-operation and development guideline 405 (acute eye irritation test). Result Pure and extracted rottlerin showed decreased intraocular pressure and reduced inflammation, lenticular opacity, and retinal damage. These results are attributed to an increase in antioxidant levels, maintenance of lipid peroxidation, enzyme level (Na+ ATPase, K+ ATPase), ionic balance (Na+, K+), and a decrease in the level of nitric oxide. Conclusion Rottlerin (pure) as well as rottlerin (extracted) has demonstrated potential in managing uveitic glaucoma. Its multifaceted mechanisms not only target inflammation and oxidative stress but also promote tissue regeneration and slow disease progression. This makes rottlerin a promising candidate for further clinical research as a potential treatment for uveitic glaucoma.https://doi.org/10.1186/s43094-025-00798-3RottlerinPKCδ inhibitorLPSInflammationAnti-oxidantsUveitic glaucoma |
| spellingShingle | Nidhi Kumari Ashmita Das Nirdesh Kumar Geeta Singh Urvashi Jain Amrita Singh Surendra H. Bodakhe Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats Future Journal of Pharmaceutical Sciences Rottlerin PKCδ inhibitor LPS Inflammation Anti-oxidants Uveitic glaucoma |
| title | Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats |
| title_full | Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats |
| title_fullStr | Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats |
| title_full_unstemmed | Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats |
| title_short | Preventive role of rottlerin in endotoxin-induced uveitic glaucoma in rats |
| title_sort | preventive role of rottlerin in endotoxin induced uveitic glaucoma in rats |
| topic | Rottlerin PKCδ inhibitor LPS Inflammation Anti-oxidants Uveitic glaucoma |
| url | https://doi.org/10.1186/s43094-025-00798-3 |
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