Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms
Neuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic presentation. An aggressive approach should be used to resec...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/782672 |
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| _version_ | 1832566992780918784 |
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| author | Palepu Jagannath Deepak Chhabra Shailesh Shrikhande Rajiv Shah |
| author_facet | Palepu Jagannath Deepak Chhabra Shailesh Shrikhande Rajiv Shah |
| author_sort | Palepu Jagannath |
| collection | DOAJ |
| description | Neuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic presentation. An aggressive approach should be used to resect the primary tumor, to remove regional lymph nodes, and to resect or treat appropriate distant metastases (including liver tumors). Despite having an indolent course, NENs have a significantly reduced survival when liver metastases are untreated. Though a wide range of therapies are now available with a multimodal approach to the treatment, surgical treatment offers the only chance for a significant survival prolongation and/or improvement of symptoms and quality of life. A review of the existing surgical modalities for NEN-LM is discussed in this paper. |
| format | Article |
| id | doaj-art-cb5d9377530146dea7676f83bb272b32 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-cb5d9377530146dea7676f83bb272b322025-02-03T01:02:41ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/782672782672Surgical Treatment of Liver Metastases in Neuroendocrine NeoplasmsPalepu Jagannath0Deepak Chhabra1Shailesh Shrikhande2Rajiv Shah3Department of Surgical Oncology, Lilavati Hospital & Research Centre, Mumbai 400 050, IndiaDepartment of Surgical Oncology, Dr. L. H. Hiranandani Hospital and Research Centre, Mumbai 400 076, IndiaDepartment of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Mumbai 400 012, IndiaDepartment of Surgical Oncology, Lilavati Hospital & Research Centre, Mumbai 400 050, IndiaNeuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic presentation. An aggressive approach should be used to resect the primary tumor, to remove regional lymph nodes, and to resect or treat appropriate distant metastases (including liver tumors). Despite having an indolent course, NENs have a significantly reduced survival when liver metastases are untreated. Though a wide range of therapies are now available with a multimodal approach to the treatment, surgical treatment offers the only chance for a significant survival prolongation and/or improvement of symptoms and quality of life. A review of the existing surgical modalities for NEN-LM is discussed in this paper.http://dx.doi.org/10.1155/2012/782672 |
| spellingShingle | Palepu Jagannath Deepak Chhabra Shailesh Shrikhande Rajiv Shah Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms International Journal of Hepatology |
| title | Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms |
| title_full | Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms |
| title_fullStr | Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms |
| title_full_unstemmed | Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms |
| title_short | Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms |
| title_sort | surgical treatment of liver metastases in neuroendocrine neoplasms |
| url | http://dx.doi.org/10.1155/2012/782672 |
| work_keys_str_mv | AT palepujagannath surgicaltreatmentoflivermetastasesinneuroendocrineneoplasms AT deepakchhabra surgicaltreatmentoflivermetastasesinneuroendocrineneoplasms AT shaileshshrikhande surgicaltreatmentoflivermetastasesinneuroendocrineneoplasms AT rajivshah surgicaltreatmentoflivermetastasesinneuroendocrineneoplasms |