Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection
The article presents the review of 94 publications. It describes experiments on latent tuberculosis infection on Cynomolgus macaques. It has been noted that in recent years, PET-CT has been used to identify thoracic lymph nodes (LN) infected with Mycobacterium tuberculosis (MTB). It has been demonst...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-09-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1454 |
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| _version_ | 1850282810160447488 |
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| author | D. A. Kuday |
| author_facet | D. A. Kuday |
| author_sort | D. A. Kuday |
| collection | DOAJ |
| description | The article presents the review of 94 publications. It describes experiments on latent tuberculosis infection on Cynomolgus macaques. It has been noted that in recent years, PET-CT has been used to identify thoracic lymph nodes (LN) infected with Mycobacterium tuberculosis (MTB). It has been demonstrated that FDG-PET-CT allows concluding about the presence of viable MTB in thoracic LNs in case of latent tuberculosis infection which is confirmed by detection of live MTB in granulomas of these LNs by culture. The preventive therapy contributes to a significant reduction of pathology visible on PET-CT. The review analyzes publications that experimentally show the spectrum of the immune response to MTB-specific proteins ESAT-6 and CFP10 in case of tuberculosis infection, in particular, the relationship between the cytokine response and bacterial load. |
| format | Article |
| id | doaj-art-cb568fbd05664cf5b8f2c2d27b12d246 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-cb568fbd05664cf5b8f2c2d27b12d2462025-08-20T01:47:52ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062020-09-01988637410.21292/2075-1230-2020-98-8-63-741453Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infectionD. A. Kuday0Immunology Research Institute by the Federal Medical Biological Agency; I. M. Sechenov First Moscow State Medical UniversityThe article presents the review of 94 publications. It describes experiments on latent tuberculosis infection on Cynomolgus macaques. It has been noted that in recent years, PET-CT has been used to identify thoracic lymph nodes (LN) infected with Mycobacterium tuberculosis (MTB). It has been demonstrated that FDG-PET-CT allows concluding about the presence of viable MTB in thoracic LNs in case of latent tuberculosis infection which is confirmed by detection of live MTB in granulomas of these LNs by culture. The preventive therapy contributes to a significant reduction of pathology visible on PET-CT. The review analyzes publications that experimentally show the spectrum of the immune response to MTB-specific proteins ESAT-6 and CFP10 in case of tuberculosis infection, in particular, the relationship between the cytokine response and bacterial load.https://www.tibl-journal.com/jour/article/view/1454latent tuberculosis infectionimmunological testsbiomarkersщ |
| spellingShingle | D. A. Kuday Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection Туберкулез и болезни лёгких latent tuberculosis infection immunological tests biomarkersщ |
| title | Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection |
| title_full | Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection |
| title_fullStr | Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection |
| title_full_unstemmed | Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection |
| title_short | Biomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infection |
| title_sort | biomarkers and immunological tests experimental and clinical parallels of latent tuberculosis infection |
| topic | latent tuberculosis infection immunological tests biomarkersщ |
| url | https://www.tibl-journal.com/jour/article/view/1454 |
| work_keys_str_mv | AT dakuday biomarkersandimmunologicaltestsexperimentalandclinicalparallelsoflatenttuberculosisinfection |