Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes
Background The relationship between hyperuricemia and chronic kidney disease (CKD) has been investigated extensively. However, studies on elderly individuals are still limited. Moreover, there is no consensus on whether hyperuricemia or elevated serum uric acid (SUA) within the normal range is corre...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238825 |
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| author | Qing Zhou Sisi Ke Yaqiong Yan Yan Guo Qing Liu |
| author_facet | Qing Zhou Sisi Ke Yaqiong Yan Yan Guo Qing Liu |
| author_sort | Qing Zhou |
| collection | DOAJ |
| description | Background The relationship between hyperuricemia and chronic kidney disease (CKD) has been investigated extensively. However, studies on elderly individuals are still limited. Moreover, there is no consensus on whether hyperuricemia or elevated serum uric acid (SUA) within the normal range is correlated with the new onset of CKD and whether there are differences between males and females.Methods We included 39039 elderly diabetic patients without CKD at baseline from a community-based cohort in Wuhan, China. The outcome event was the new onset of CKD (defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2). Multivariate Cox models were used to assess the adjusted hazard ratio (HR).Results During the 2-year follow-up period, 3162 (8.10%) patients with diabetes developed new-onset CKD. The optimal cutoff value of SUA for incident CKD was 347.4 μmol/L. The adjusted HRs of hyperuricemia for new-onset CKD were 1.925 (1.724–2.150) and 1.676 (1.520–1.848) for males and females, respectively. The risk of developing CKD increased across the Q4 group up to 2.242 times for their counterparts in the lowest SUA quartile, independent of age, sex, diabetes duration, obesity, hypertension, systolic blood pressure, diastolic blood pressure, smoking, drinking, dyslipidemia, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting plasma glucose.Conclusions Hyperuricemia is an independent predictor of incident CKD. Elevated SUA was linearly correlated with CKD in elderly patients with diabetes, showing a relatively higher intensity among males compared with that among females. The optimal cutoff value of SUA for the risk of new-onset CKD in elderly patients with diabetes was 347.4 μmol/L. |
| format | Article |
| id | doaj-art-cb4e86124bdd4b9c82e64e64e3f4557b |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-cb4e86124bdd4b9c82e64e64e3f4557b2025-08-20T02:28:46ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2238825Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetesQing Zhou0Sisi Ke1Yaqiong Yan2Yan Guo3Qing Liu4Department of Epidemiology, School of Public Health, Wuhan University, Wuhan, Hubei, P.R. ChinaWuhan Centers for Disease Control & Prevention, Wuhan, Hubei, P.R. ChinaWuhan Centers for Disease Control & Prevention, Wuhan, Hubei, P.R. ChinaWuhan Centers for Disease Control & Prevention, Wuhan, Hubei, P.R. ChinaDepartment of Epidemiology, School of Public Health, Wuhan University, Wuhan, Hubei, P.R. ChinaBackground The relationship between hyperuricemia and chronic kidney disease (CKD) has been investigated extensively. However, studies on elderly individuals are still limited. Moreover, there is no consensus on whether hyperuricemia or elevated serum uric acid (SUA) within the normal range is correlated with the new onset of CKD and whether there are differences between males and females.Methods We included 39039 elderly diabetic patients without CKD at baseline from a community-based cohort in Wuhan, China. The outcome event was the new onset of CKD (defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2). Multivariate Cox models were used to assess the adjusted hazard ratio (HR).Results During the 2-year follow-up period, 3162 (8.10%) patients with diabetes developed new-onset CKD. The optimal cutoff value of SUA for incident CKD was 347.4 μmol/L. The adjusted HRs of hyperuricemia for new-onset CKD were 1.925 (1.724–2.150) and 1.676 (1.520–1.848) for males and females, respectively. The risk of developing CKD increased across the Q4 group up to 2.242 times for their counterparts in the lowest SUA quartile, independent of age, sex, diabetes duration, obesity, hypertension, systolic blood pressure, diastolic blood pressure, smoking, drinking, dyslipidemia, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting plasma glucose.Conclusions Hyperuricemia is an independent predictor of incident CKD. Elevated SUA was linearly correlated with CKD in elderly patients with diabetes, showing a relatively higher intensity among males compared with that among females. The optimal cutoff value of SUA for the risk of new-onset CKD in elderly patients with diabetes was 347.4 μmol/L.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238825Serum uric acidchronic kidney diseaseelderlydiabetes |
| spellingShingle | Qing Zhou Sisi Ke Yaqiong Yan Yan Guo Qing Liu Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes Renal Failure Serum uric acid chronic kidney disease elderly diabetes |
| title | Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes |
| title_full | Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes |
| title_fullStr | Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes |
| title_full_unstemmed | Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes |
| title_short | Serum uric acid is associated with chronic kidney disease in elderly Chinese patients with diabetes |
| title_sort | serum uric acid is associated with chronic kidney disease in elderly chinese patients with diabetes |
| topic | Serum uric acid chronic kidney disease elderly diabetes |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238825 |
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