LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION
The activity of an inflammatory process, the visceral manifestations of rheumatoid arthritis (RA), and arterial hypertension (AH) are usually initiators and accelerators of the progression and complicated course of atherosclerosis and the remodeling of the left cardiac chambers (LCC). Objective: to...
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IMA PRESS LLC
2013-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1106 |
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| author | D A Khalilova B D Nazarov Yor Umarovich Saidov R N Zubaidov |
| author_facet | D A Khalilova B D Nazarov Yor Umarovich Saidov R N Zubaidov |
| author_sort | D A Khalilova |
| collection | DOAJ |
| description | The activity of an inflammatory process, the visceral manifestations of rheumatoid arthritis (RA), and arterial hypertension (AH) are usually initiators and accelerators of the progression and complicated course of atherosclerosis and the remodeling of the left cardiac chambers (LCC). Objective: to study the pattern and possible pathogenetic aspects of LCC structural and functional changes in patients with RA in view of the clinical and immunological features of the disease and the presence of AH. Subjects and methods. The trial enrolled 103 patients (84 women and 19 men) (mean age 46.3+3.4 years), with the reliable and valid diagnosis of RA (mean duration 8.2+1.6 years). Forty-six patients of them had different systemic manifestations and, by the beginning of a follow-up, AH was verified in 54. All the included patients underwent echocardiographic study to analyze the generally accepted structural and morphological parameters of LCC. Results. The patients with RA as the disease progresses and is concurrent with AH develop LCC structural and functional rearrangement, the major components of which were the development of left ventricular concentric hypertrophy and diastolic dysfunction, the hyperkinetic type of hemodynamics, and the spherization of LCC. The findings show that the basis of LCC remodeling in RA is a set of closely related factors, mainly the activity and systemic pattern of rheumatoid arthritis, and AH, which generally allows the LCC structural rearrangement to be regarded as a unique pathological process. |
| format | Article |
| id | doaj-art-cb4b0e6fb9f0476b981640dc6016bc83 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2013-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-cb4b0e6fb9f0476b981640dc6016bc832025-08-20T04:00:38ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922013-02-01511212710.14412/1995-4484-2013-11961046LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSIOND A Khalilova0B D Nazarov1Yor Umarovich Saidov2R N Zubaidov3Таджикский государственный медицинский университет им. Абуали ибн Сино, ДушанбеТаджикский государственный медицинский университет им. Абуали ибн Сино, ДушанбеТаджикский государственный медицинский университет им. Абуали ибн Сино, ДушанбеТаджикский государственный медицинский университет им. Абуали ибн Сино, ДушанбеThe activity of an inflammatory process, the visceral manifestations of rheumatoid arthritis (RA), and arterial hypertension (AH) are usually initiators and accelerators of the progression and complicated course of atherosclerosis and the remodeling of the left cardiac chambers (LCC). Objective: to study the pattern and possible pathogenetic aspects of LCC structural and functional changes in patients with RA in view of the clinical and immunological features of the disease and the presence of AH. Subjects and methods. The trial enrolled 103 patients (84 women and 19 men) (mean age 46.3+3.4 years), with the reliable and valid diagnosis of RA (mean duration 8.2+1.6 years). Forty-six patients of them had different systemic manifestations and, by the beginning of a follow-up, AH was verified in 54. All the included patients underwent echocardiographic study to analyze the generally accepted structural and morphological parameters of LCC. Results. The patients with RA as the disease progresses and is concurrent with AH develop LCC structural and functional rearrangement, the major components of which were the development of left ventricular concentric hypertrophy and diastolic dysfunction, the hyperkinetic type of hemodynamics, and the spherization of LCC. The findings show that the basis of LCC remodeling in RA is a set of closely related factors, mainly the activity and systemic pattern of rheumatoid arthritis, and AH, which generally allows the LCC structural rearrangement to be regarded as a unique pathological process.https://rsp.mediar-press.net/rsp/article/view/1106rheumatoid arthritisarterial hypertensionleft cardiac chambershypertrophymorphofunctional parametersleft ventricular diastolic dysfunction |
| spellingShingle | D A Khalilova B D Nazarov Yor Umarovich Saidov R N Zubaidov LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION Научно-практическая ревматология rheumatoid arthritis arterial hypertension left cardiac chambers hypertrophy morphofunctional parameters left ventricular diastolic dysfunction |
| title | LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION |
| title_full | LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION |
| title_fullStr | LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION |
| title_full_unstemmed | LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION |
| title_short | LEFT HEART STRUCTURE AND FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CLINICAL AND IMMUNOLOGICAL FEATURES OF THE DISEASE AND THE PRESENCE OF ARTERIAL HYPERTENSION |
| title_sort | left heart structure and function in patients with rheumatoid arthritis association with the clinical and immunological features of the disease and the presence of arterial hypertension |
| topic | rheumatoid arthritis arterial hypertension left cardiac chambers hypertrophy morphofunctional parameters left ventricular diastolic dysfunction |
| url | https://rsp.mediar-press.net/rsp/article/view/1106 |
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