Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases
Emerging as a paradigm-shifting therapeutic strategy initially developed for hematological malignancies, chimeric antigen receptor (CAR)-based cell therapy has recently proved transformative potential in autoimmune disease management. CAR T cell therapy has achieved long-term remission without drugs...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2538350 |
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| author | Mingwei Jiang Jin Zhao Jinguo Yuan Zixian Yu Jie Liu Zhanxin Zhu Xiaoxuan Ning Shiren Sun |
| author_facet | Mingwei Jiang Jin Zhao Jinguo Yuan Zixian Yu Jie Liu Zhanxin Zhu Xiaoxuan Ning Shiren Sun |
| author_sort | Mingwei Jiang |
| collection | DOAJ |
| description | Emerging as a paradigm-shifting therapeutic strategy initially developed for hematological malignancies, chimeric antigen receptor (CAR)-based cell therapy has recently proved transformative potential in autoimmune disease management. CAR T cell therapy has achieved long-term remission without drugs in a variety of autoimmune diseases. Chimeric autoantigen receptor T cell therapy targeting specific B cell receptors has transitioned from preclinical research to clinical trials. CAR natural killer cell therapy has shown promising efficacy and safety in early-stage clinical trials. The evolution of CAR regulatory T cell and mesenchymal stem cell therapy has also achieved initial results. These achievements have greatly inspired researchers, and more research is being actively carried out in the field of autoimmune diseases, aiming to develop more efficient, safe and convenient cell products. This article will detail the effectiveness and applicability of CAR-based immunotherapy in the management of autoimmune diseases, and explore its limitations and future trends. |
| format | Article |
| id | doaj-art-cb48b33bedd8420aa92c1d9ac38244bb |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-cb48b33bedd8420aa92c1d9ac38244bb2025-08-20T03:16:18ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2538350Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseasesMingwei Jiang0Jin Zhao1Jinguo Yuan2Zixian Yu3Jie Liu4Zhanxin Zhu5Xiaoxuan Ning6Shiren Sun7Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaDepartment of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, The Fourth Military Medical University, Shaanxi Provincial Clinical Research Center for Kidney Diseases, Xi’an, Shaanxi, ChinaEmerging as a paradigm-shifting therapeutic strategy initially developed for hematological malignancies, chimeric antigen receptor (CAR)-based cell therapy has recently proved transformative potential in autoimmune disease management. CAR T cell therapy has achieved long-term remission without drugs in a variety of autoimmune diseases. Chimeric autoantigen receptor T cell therapy targeting specific B cell receptors has transitioned from preclinical research to clinical trials. CAR natural killer cell therapy has shown promising efficacy and safety in early-stage clinical trials. The evolution of CAR regulatory T cell and mesenchymal stem cell therapy has also achieved initial results. These achievements have greatly inspired researchers, and more research is being actively carried out in the field of autoimmune diseases, aiming to develop more efficient, safe and convenient cell products. This article will detail the effectiveness and applicability of CAR-based immunotherapy in the management of autoimmune diseases, and explore its limitations and future trends.https://www.tandfonline.com/doi/10.1080/21645515.2025.2538350Autoimmune diseaseschimeric antigen receptorsCAR TCAR NKCAR tregimmunotherapy |
| spellingShingle | Mingwei Jiang Jin Zhao Jinguo Yuan Zixian Yu Jie Liu Zhanxin Zhu Xiaoxuan Ning Shiren Sun Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases Human Vaccines & Immunotherapeutics Autoimmune diseases chimeric antigen receptors CAR T CAR NK CAR treg immunotherapy |
| title | Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases |
| title_full | Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases |
| title_fullStr | Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases |
| title_full_unstemmed | Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases |
| title_short | Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases |
| title_sort | research progress on chimeric antigen receptor based immunotherapy against autoimmune diseases |
| topic | Autoimmune diseases chimeric antigen receptors CAR T CAR NK CAR treg immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2538350 |
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