Celastrol targets CKB-mediated futile creatine cycle in human brown adipocytes thermogenesis

Celastrol targets CKB-mediated futile creatine cycle in human brown adipocytes thermogenesis

Celastrol is widely recognized as one of the most potent anti-obesity agents, and its ability to promote adipocyte thermogenesis is thought to be a key mechanism. However, the precise molecular targets through which celastrol modulates thermogenesis in human adipocytes remain unclear. In this study,...

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Bibliographic Details
Main Authors: Jingyi Ni, Baicheng Wang, Xinyue Liu, Rui Yin, Jinlin Tang, Siyu Hua, Xiaoxiao Zhang, Yangyang Wu, Shihu Zhang, Chenbo Ji
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Metabolism Open
Subjects:
Celastrol
Thermogenesis
CKB
Futile creatine cycle
Human adipocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2589936825000155
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