Neurolymphomatosis: A surreal presentation of lymphoma

Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root co...

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Main Authors: Shikha Khandelwal, Suvinay Saxena, Disha J Hansalia
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2017-01-01
Series:Indian Journal of Medical and Paediatric Oncology
Subjects:
Online Access:http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=3;spage=287;epage=290;aulast=Khandelwal
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author Shikha Khandelwal
Suvinay Saxena
Disha J Hansalia
author_facet Shikha Khandelwal
Suvinay Saxena
Disha J Hansalia
author_sort Shikha Khandelwal
collection DOAJ
description Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET). Results and Conclusion: MRI and PET-CT are imaging modalities of choice for evaluation of patients with lymphoma and suspected neural involvement. Treatment of neurolymphomatosis consists of focal radiotherapy and high-dose methotrexate therapy.
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spelling doaj-art-cb46d6103adb433c93c98a0272bbfba92025-08-20T02:28:04ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512017-01-0138328729010.4103/ijmpo.ijmpo_151_16Neurolymphomatosis: A surreal presentation of lymphomaShikha KhandelwalSuvinay SaxenaDisha J HansaliaBackground: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET). Results and Conclusion: MRI and PET-CT are imaging modalities of choice for evaluation of patients with lymphoma and suspected neural involvement. Treatment of neurolymphomatosis consists of focal radiotherapy and high-dose methotrexate therapy.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=3;spage=287;epage=290;aulast=KhandelwalLymphomamagnetic resonance imagingneurolymphomatosispositron emission tomography-computed tomography imaging
spellingShingle Shikha Khandelwal
Suvinay Saxena
Disha J Hansalia
Neurolymphomatosis: A surreal presentation of lymphoma
Indian Journal of Medical and Paediatric Oncology
Lymphoma
magnetic resonance imaging
neurolymphomatosis
positron emission tomography-computed tomography imaging
title Neurolymphomatosis: A surreal presentation of lymphoma
title_full Neurolymphomatosis: A surreal presentation of lymphoma
title_fullStr Neurolymphomatosis: A surreal presentation of lymphoma
title_full_unstemmed Neurolymphomatosis: A surreal presentation of lymphoma
title_short Neurolymphomatosis: A surreal presentation of lymphoma
title_sort neurolymphomatosis a surreal presentation of lymphoma
topic Lymphoma
magnetic resonance imaging
neurolymphomatosis
positron emission tomography-computed tomography imaging
url http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=3;spage=287;epage=290;aulast=Khandelwal
work_keys_str_mv AT shikhakhandelwal neurolymphomatosisasurrealpresentationoflymphoma
AT suvinaysaxena neurolymphomatosisasurrealpresentationoflymphoma
AT dishajhansalia neurolymphomatosisasurrealpresentationoflymphoma