Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm
The active avoidance paradigm is a reliable tool for the assessment of associative learning/memory. Nutritional manipulation is an emerging approach for the improvisation of brain health. Syzygium cumini (SC) fruit with enriched phytoconstituents, was investigated in varied concentrations on the lea...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006443 |
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| author | Nosheen Malik Hammad Murtaza Waseem Ashraf Muhammad Fawad Rasool Farhan Siddique Maryam Bashir Tanveer Ahmad Faleh Alqahtani Imran Imran |
| author_facet | Nosheen Malik Hammad Murtaza Waseem Ashraf Muhammad Fawad Rasool Farhan Siddique Maryam Bashir Tanveer Ahmad Faleh Alqahtani Imran Imran |
| author_sort | Nosheen Malik |
| collection | DOAJ |
| description | The active avoidance paradigm is a reliable tool for the assessment of associative learning/memory. Nutritional manipulation is an emerging approach for the improvisation of brain health. Syzygium cumini (SC) fruit with enriched phytoconstituents, was investigated in varied concentrations on the learning/memory of scopolamine-induced amnesic mice through active-avoidance protocol. Chemical characterization by UHPLC-MS and molecular docking were performed for the identification of phytoconstituents and their action on possible targets. Our results revealed that SC-supplemented mice performed well as compared to amnesic group, with significant increase in the percentage avoidance and decrease in the latency. The identified phytoconstituents may enhance the cognitive performance in treated groups because of their antioxidant potential. Moreover, in-silico studies demonstrated good binding interactions with cholinesterase enzyme possibly inhibiting it and augmenting cholinergic activity in brain. In conclusion, SC dilutions improved cognitive performance in amnesic mice possibly due to antioxidant and anticholinesterase effects exerted by phyto-compounds. |
| format | Article |
| id | doaj-art-cb45b857f8f5473f8d75132f63974fcd |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-cb45b857f8f5473f8d75132f63974fcd2025-01-12T05:24:45ZengElsevierJournal of Functional Foods1756-46462025-01-01124106641Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigmNosheen Malik0Hammad Murtaza1Waseem Ashraf2Muhammad Fawad Rasool3Farhan Siddique4Maryam Bashir5Tanveer Ahmad6Faleh Alqahtani7Imran Imran8Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanInstitut pour l'Avancée des Biosciences, Centre de Recherche UGA/INSERM U1209/CNRS 5309, Université Grenoble Alpes, FranceDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan; Corresponding author at: Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, 60800 Multan, Pakistan.The active avoidance paradigm is a reliable tool for the assessment of associative learning/memory. Nutritional manipulation is an emerging approach for the improvisation of brain health. Syzygium cumini (SC) fruit with enriched phytoconstituents, was investigated in varied concentrations on the learning/memory of scopolamine-induced amnesic mice through active-avoidance protocol. Chemical characterization by UHPLC-MS and molecular docking were performed for the identification of phytoconstituents and their action on possible targets. Our results revealed that SC-supplemented mice performed well as compared to amnesic group, with significant increase in the percentage avoidance and decrease in the latency. The identified phytoconstituents may enhance the cognitive performance in treated groups because of their antioxidant potential. Moreover, in-silico studies demonstrated good binding interactions with cholinesterase enzyme possibly inhibiting it and augmenting cholinergic activity in brain. In conclusion, SC dilutions improved cognitive performance in amnesic mice possibly due to antioxidant and anticholinesterase effects exerted by phyto-compounds.http://www.sciencedirect.com/science/article/pii/S1756464624006443Active avoidance testSyzygium cuminiLearningMemoryScopolamine-induced amnesia |
| spellingShingle | Nosheen Malik Hammad Murtaza Waseem Ashraf Muhammad Fawad Rasool Farhan Siddique Maryam Bashir Tanveer Ahmad Faleh Alqahtani Imran Imran Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm Journal of Functional Foods Active avoidance test Syzygium cumini Learning Memory Scopolamine-induced amnesia |
| title | Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm |
| title_full | Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm |
| title_fullStr | Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm |
| title_full_unstemmed | Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm |
| title_short | Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm |
| title_sort | syzygium cumini fresh juice ameliorated memory impairment in a scopolamine induced amnesic mouse model through active avoidance paradigm |
| topic | Active avoidance test Syzygium cumini Learning Memory Scopolamine-induced amnesia |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006443 |
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