Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry
ABSTRACT The physiological and biophysical knowledge base for interpretations of cerebrospinal fluid (CSF) data and reference ranges are essential for the clinical pathologist and neurochemist. With the popular description of the CSF flow dependent barrier function, the dynamics and concentration gr...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2016-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600501&lng=en&tlng=en |
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| _version_ | 1849696313076088832 |
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| author | Hansotto Reiber |
| author_facet | Hansotto Reiber |
| author_sort | Hansotto Reiber |
| collection | DOAJ |
| description | ABSTRACT The physiological and biophysical knowledge base for interpretations of cerebrospinal fluid (CSF) data and reference ranges are essential for the clinical pathologist and neurochemist. With the popular description of the CSF flow dependent barrier function, the dynamics and concentration gradients of blood-derived, brain-derived and leptomeningeal proteins in CSF or the specificity-independent functions of B-lymphocytes in brain also the neurologist, psychiatrist, neurosurgeon as well as the neuropharmacologist may find essentials for diagnosis, research or development of therapies. This review may help to replace the outdated ideas like “leakage” models of the barriers, linear immunoglobulin Index Interpretations or CSF electrophoresis. Calculations, Interpretations and analytical pitfalls are described for albumin quotients, quantitation of immunoglobulin synthesis in Reibergrams, oligoclonal IgG, IgM analysis, the polyspecific ( MRZ- ) antibody reaction, the statistical treatment of CSF data and general quality assessment in the CSF laboratory. The diagnostic relevance is documented in an accompaning review. |
| format | Article |
| id | doaj-art-cb442115b6284a998c5fb98916b1c19e |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-cb442115b6284a998c5fb98916b1c19e2025-08-20T03:19:31ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272016-06-0174650151210.1590/0004-282X20160066S0004-282X2016000600501Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatryHansotto ReiberABSTRACT The physiological and biophysical knowledge base for interpretations of cerebrospinal fluid (CSF) data and reference ranges are essential for the clinical pathologist and neurochemist. With the popular description of the CSF flow dependent barrier function, the dynamics and concentration gradients of blood-derived, brain-derived and leptomeningeal proteins in CSF or the specificity-independent functions of B-lymphocytes in brain also the neurologist, psychiatrist, neurosurgeon as well as the neuropharmacologist may find essentials for diagnosis, research or development of therapies. This review may help to replace the outdated ideas like “leakage” models of the barriers, linear immunoglobulin Index Interpretations or CSF electrophoresis. Calculations, Interpretations and analytical pitfalls are described for albumin quotients, quantitation of immunoglobulin synthesis in Reibergrams, oligoclonal IgG, IgM analysis, the polyspecific ( MRZ- ) antibody reaction, the statistical treatment of CSF data and general quality assessment in the CSF laboratory. The diagnostic relevance is documented in an accompaning review.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600501&lng=en&tlng=enlíquido cefalorraquidianovalores de referênciaimunoglobulinasalbumin |
| spellingShingle | Hansotto Reiber Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry Arquivos de Neuro-Psiquiatria líquido cefalorraquidiano valores de referência imunoglobulinas albumin |
| title | Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry |
| title_full | Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry |
| title_fullStr | Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry |
| title_full_unstemmed | Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry |
| title_short | Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry |
| title_sort | knowledge base for interpretation of cerebrospinal fluid data patterns essentials in neurology and psychiatry |
| topic | líquido cefalorraquidiano valores de referência imunoglobulinas albumin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600501&lng=en&tlng=en |
| work_keys_str_mv | AT hansottoreiber knowledgebaseforinterpretationofcerebrospinalfluiddatapatternsessentialsinneurologyandpsychiatry |