Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy
Objective: We investigated oxidative status in patients with rotator cuff tendinopathy (RCT) and evaluated their relationship with radiological and clinical parameters. Methods: In this cross-section study, 88 patients with RCT (59 males and 29 females) and 86 healthy controls (66 males, 20 femal...
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AVES
2024-05-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | https://www.aott.org.tr/en/preliminary-results-of-clinical-biochemical-and-radiological-investigation-into-the-oxidative-status-in-patients-with-rotator-cuff-tendinopathy-137401 |
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| author | Cemil Ertürk Gürkan Çalışkan Özcan Erel |
| author_facet | Cemil Ertürk Gürkan Çalışkan Özcan Erel |
| author_sort | Cemil Ertürk |
| collection | DOAJ |
| description | Objective: We investigated oxidative status in patients with rotator cuff tendinopathy (RCT) and evaluated their relationship with radiological and clinical parameters.
Methods: In this cross-section study, 88 patients with RCT (59 males and 29 females) and 86 healthy controls (66 males, 20 females) were enrolled. The sample consisted of nontraumatic patients who are suffering from shoulder pain because of rotator cuff disease, which was established by clinical tests and MRI scanning. Oxidative stress in patients with RCT was analyzed via the dynamic thiol/disulfide homeostasis (TDH). Thiol/disulfide homeostasis was measured by a new colorimetric method. Furthermore, oxidative stress was indirectly measured by serum total oxidant status (TOS), oxidative stress index (OSI), and total antioxidant capacity (TAC).
Results: Serum disulfide levels and the other oxidative stress parameters of the RCT group were significantly greater than those of the control group (P < .001 for all), whereas the anti-oxidative stress parameters remained unchanged (P > .05 for all). The lowest and highest serum disulfide levels were detected in patients with grades 1 and 3, respectively (P < .001). Furthermore, in a multiple regression analysis, the disulfide/natural thiol ratio (β=–4.886, P = .004) and the MRI grading (β=0.314, P=.001) were independently associated with the Western Ontario Rotator Cuff Index WORC score.
Conclusion: We found an association between the levels of various serum markers of oxidative injury, especially serum disulfide levels, and the increasing severity of RCT. Thiol/disulfide homeostasis seems to play a critical role in RCT, both in the beginning and during the progression of disease.
Level of Evidence: Level III, Diagnostic study. |
| format | Article |
| id | doaj-art-cb32e57beccc41d589dc180d68957334 |
| institution | Kabale University |
| issn | 1017-995X |
| language | English |
| publishDate | 2024-05-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj-art-cb32e57beccc41d589dc180d689573342025-08-20T03:38:49ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2024-05-0158316116610.5152/j.aott.2024.22030Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathyCemil Ertürk 0Gürkan Çalışkan1Özcan Erel2Department of Orthopaedic Surgery, University of Health Sciences, Hamidiye Faculty of Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Kucukcekmece, Istanbul, TürkiyeDepartment of Orthopaedic Surgery, University of Health Sciences, Hamidiye Faculty of Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Kucukcekmece, Istanbul, TürkiyeDepartment of Clinical Biochemistry, Yildirim Beyazit University School of Medicine, Ankara, TürkiyeObjective: We investigated oxidative status in patients with rotator cuff tendinopathy (RCT) and evaluated their relationship with radiological and clinical parameters. Methods: In this cross-section study, 88 patients with RCT (59 males and 29 females) and 86 healthy controls (66 males, 20 females) were enrolled. The sample consisted of nontraumatic patients who are suffering from shoulder pain because of rotator cuff disease, which was established by clinical tests and MRI scanning. Oxidative stress in patients with RCT was analyzed via the dynamic thiol/disulfide homeostasis (TDH). Thiol/disulfide homeostasis was measured by a new colorimetric method. Furthermore, oxidative stress was indirectly measured by serum total oxidant status (TOS), oxidative stress index (OSI), and total antioxidant capacity (TAC). Results: Serum disulfide levels and the other oxidative stress parameters of the RCT group were significantly greater than those of the control group (P < .001 for all), whereas the anti-oxidative stress parameters remained unchanged (P > .05 for all). The lowest and highest serum disulfide levels were detected in patients with grades 1 and 3, respectively (P < .001). Furthermore, in a multiple regression analysis, the disulfide/natural thiol ratio (β=–4.886, P = .004) and the MRI grading (β=0.314, P=.001) were independently associated with the Western Ontario Rotator Cuff Index WORC score. Conclusion: We found an association between the levels of various serum markers of oxidative injury, especially serum disulfide levels, and the increasing severity of RCT. Thiol/disulfide homeostasis seems to play a critical role in RCT, both in the beginning and during the progression of disease. Level of Evidence: Level III, Diagnostic study.https://www.aott.org.tr/en/preliminary-results-of-clinical-biochemical-and-radiological-investigation-into-the-oxidative-status-in-patients-with-rotator-cuff-tendinopathy-137401 |
| spellingShingle | Cemil Ertürk Gürkan Çalışkan Özcan Erel Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy Acta Orthopaedica et Traumatologica Turcica |
| title | Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy |
| title_full | Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy |
| title_fullStr | Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy |
| title_full_unstemmed | Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy |
| title_short | Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy |
| title_sort | preliminary results of clinical biochemical and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy |
| url | https://www.aott.org.tr/en/preliminary-results-of-clinical-biochemical-and-radiological-investigation-into-the-oxidative-status-in-patients-with-rotator-cuff-tendinopathy-137401 |
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