Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes
Abstract The biotransformation of nanoparticles plays a crucial role in determining their biological fate and responses. Although a few engineering strategies (e.g., surface functionalization and shape control) have been employed to regulate the fate of nanoparticles, the genetic control of nanopart...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58520-z |
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| author | Mingming Tian Di Wu Xiao Gou Ruibin Li Xiaowei Zhang |
| author_facet | Mingming Tian Di Wu Xiao Gou Ruibin Li Xiaowei Zhang |
| author_sort | Mingming Tian |
| collection | DOAJ |
| description | Abstract The biotransformation of nanoparticles plays a crucial role in determining their biological fate and responses. Although a few engineering strategies (e.g., surface functionalization and shape control) have been employed to regulate the fate of nanoparticles, the genetic control of nanoparticle biotransformation remains an unexplored avenue. Herein, we utilized a CRISPR-based genome-scale knockout approach to identify genes involved in the biotransformation of rare earth oxide (REO) nanoparticles. We found that the biotransformation of REOs in lysosomes could be genetically controlled via SMPD1. Specifically, suppression of SMPD1 inhibited the transformation of La2O3 into sea urchin-shaped structures, thereby protecting against lysosomal damage, proinflammatory cytokine release, pyroptosis and RE-induced pneumoconiosis. Overall, our study provides insight into how to control the biological fate of nanomaterials. |
| format | Article |
| id | doaj-art-cb2eae0b7e3641d89d58bdc23135a006 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-cb2eae0b7e3641d89d58bdc23135a0062025-08-20T02:11:42ZengNature PortfolioNature Communications2041-17232025-04-0116111310.1038/s41467-025-58520-zGenetic modulation of rare earth nanoparticle biotransformation shapes biological outcomesMingming Tian0Di Wu1Xiao Gou2Ruibin Li3Xiaowei Zhang4School of Ecology and Environmental Science, Yunnan University & Yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded EnvironmentsState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow Medical College, Soochow UniversityState Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing UniversityState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow Medical College, Soochow UniversitySchool of Ecology and Environmental Science, Yunnan University & Yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded EnvironmentsAbstract The biotransformation of nanoparticles plays a crucial role in determining their biological fate and responses. Although a few engineering strategies (e.g., surface functionalization and shape control) have been employed to regulate the fate of nanoparticles, the genetic control of nanoparticle biotransformation remains an unexplored avenue. Herein, we utilized a CRISPR-based genome-scale knockout approach to identify genes involved in the biotransformation of rare earth oxide (REO) nanoparticles. We found that the biotransformation of REOs in lysosomes could be genetically controlled via SMPD1. Specifically, suppression of SMPD1 inhibited the transformation of La2O3 into sea urchin-shaped structures, thereby protecting against lysosomal damage, proinflammatory cytokine release, pyroptosis and RE-induced pneumoconiosis. Overall, our study provides insight into how to control the biological fate of nanomaterials.https://doi.org/10.1038/s41467-025-58520-z |
| spellingShingle | Mingming Tian Di Wu Xiao Gou Ruibin Li Xiaowei Zhang Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes Nature Communications |
| title | Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes |
| title_full | Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes |
| title_fullStr | Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes |
| title_full_unstemmed | Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes |
| title_short | Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes |
| title_sort | genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes |
| url | https://doi.org/10.1038/s41467-025-58520-z |
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