Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Abstract Hydrocephalus, characterized by ventriculomegaly due to cerebrospinal fluid accumulation in the cerebral ventricles, is a co-morbidity factor in several neurodevelopmental, psychiatric and neurodegenerative diseases. Aquaporin-4 (AQP4) is crucial for brain water homeostasis, with Aqp4 knock...

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Main Authors: Jose A. Fernández-Albarral, Ana Simón-García, Elena Salobrar-García, Juan J. Salazar, Celia López-Menéndez, Luis S. M. Pajuelo, Jose A. Matamoros, Rosa de Hoz, Inés López-Cuenca, Lorena Elvira-Hurtado, Lidia Sanchez-Puebla, Marina P. Sánchez-Carralero, Marina Sanz, José M. Ramírez, Teresa Iglesias, Ana I. Ramírez
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Retina
AQP4
Ventriculomegaly
Hydrocephalus
Kidins220
VPS35
Online Access:https://doi.org/10.1186/s12987-025-00626-z
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