The effectiveness of lithium ascorbate on chronic alcohol intoxication model
The alcohol leads to deviant behavior in animals, increases aggression and irreversible degenerative changes in the liver and in the central nervous system. Lithium ascorbate in dose of 5 mg/kg, as well as higher doses (10 and 30 mg/kg), activates adaptive mechanisms normalizing behavioral responses...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2017-02-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/4 |
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| author | K. V. Ostrenko O. A. Gromova I. S. Sardaryan V. I. Demidov N. Yu. Zhidomorov I. Yu. Torshin A. V. Pronin V. A. Krivonogov Yu. V. Karpunina |
| author_facet | K. V. Ostrenko O. A. Gromova I. S. Sardaryan V. I. Demidov N. Yu. Zhidomorov I. Yu. Torshin A. V. Pronin V. A. Krivonogov Yu. V. Karpunina |
| author_sort | K. V. Ostrenko |
| collection | DOAJ |
| description | The alcohol leads to deviant behavior in animals, increases aggression and irreversible degenerative changes in the liver and in the central nervous system. Lithium ascorbate in dose of 5 mg/kg, as well as higher doses (10 and 30 mg/kg), activates adaptive mechanisms normalizing behavioral responses in the tests «open field» and «elevated plus-maze». Histological analysis showed that lithium ascorbate minimize ischemic damage of neurocytes to a reversible state. In general, the use of lithium ascorbate contributes to relief of withdrawal symptoms, inhibited the occurrence of seizures and contributed to preservation of the function of the central nervous system in the model of chronic alcohol intoxication. |
| format | Article |
| id | doaj-art-cb292b03fe92429e93fa06a95a4ba613 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2017-02-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-cb292b03fe92429e93fa06a95a4ba6132025-08-20T03:42:26ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302017-02-010111213The effectiveness of lithium ascorbate on chronic alcohol intoxication modelK. V. Ostrenko0O. A. Gromova1I. S. Sardaryan2V. I. Demidov3N. Yu. Zhidomorov4I. Yu. Torshin5A. V. Pronin6V. A. Krivonogov7Yu. V. Karpunina8FGBNU «Institute of Physiology, Biochemistry and Nutrition of Animals»«Ivanovo State Medical Academy»FFSBI HPE «Saint Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation«Ivanovo State Medical Academy»«Ivanovo State Medical Academy»Moscow Institute of Physics and Technology (State University)«Ivanovo State Medical Academy»«Ivanovo State Medical Academy»«Ivanovo State Medical Academy»The alcohol leads to deviant behavior in animals, increases aggression and irreversible degenerative changes in the liver and in the central nervous system. Lithium ascorbate in dose of 5 mg/kg, as well as higher doses (10 and 30 mg/kg), activates adaptive mechanisms normalizing behavioral responses in the tests «open field» and «elevated plus-maze». Histological analysis showed that lithium ascorbate minimize ischemic damage of neurocytes to a reversible state. In general, the use of lithium ascorbate contributes to relief of withdrawal symptoms, inhibited the occurrence of seizures and contributed to preservation of the function of the central nervous system in the model of chronic alcohol intoxication.https://www.pharmacokinetica.ru/jour/article/view/4алкогольная интоксикацияаскорбат литиянормотимalcohol intoxicationlithium ascorbatenormotim |
| spellingShingle | K. V. Ostrenko O. A. Gromova I. S. Sardaryan V. I. Demidov N. Yu. Zhidomorov I. Yu. Torshin A. V. Pronin V. A. Krivonogov Yu. V. Karpunina The effectiveness of lithium ascorbate on chronic alcohol intoxication model Фармакокинетика и Фармакодинамика алкогольная интоксикация аскорбат лития нормотим alcohol intoxication lithium ascorbate normotim |
| title | The effectiveness of lithium ascorbate on chronic alcohol intoxication model |
| title_full | The effectiveness of lithium ascorbate on chronic alcohol intoxication model |
| title_fullStr | The effectiveness of lithium ascorbate on chronic alcohol intoxication model |
| title_full_unstemmed | The effectiveness of lithium ascorbate on chronic alcohol intoxication model |
| title_short | The effectiveness of lithium ascorbate on chronic alcohol intoxication model |
| title_sort | effectiveness of lithium ascorbate on chronic alcohol intoxication model |
| topic | алкогольная интоксикация аскорбат лития нормотим alcohol intoxication lithium ascorbate normotim |
| url | https://www.pharmacokinetica.ru/jour/article/view/4 |
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