The effectiveness of lithium ascorbate on chronic alcohol intoxication model
The alcohol leads to deviant behavior in animals, increases aggression and irreversible degenerative changes in the liver and in the central nervous system. Lithium ascorbate in dose of 5 mg/kg, as well as higher doses (10 and 30 mg/kg), activates adaptive mechanisms normalizing behavioral responses...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2017-02-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/4 |
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| Summary: | The alcohol leads to deviant behavior in animals, increases aggression and irreversible degenerative changes in the liver and in the central nervous system. Lithium ascorbate in dose of 5 mg/kg, as well as higher doses (10 and 30 mg/kg), activates adaptive mechanisms normalizing behavioral responses in the tests «open field» and «elevated plus-maze». Histological analysis showed that lithium ascorbate minimize ischemic damage of neurocytes to a reversible state. In general, the use of lithium ascorbate contributes to relief of withdrawal symptoms, inhibited the occurrence of seizures and contributed to preservation of the function of the central nervous system in the model of chronic alcohol intoxication. |
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| ISSN: | 2587-7836 2686-8830 |