Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases
Uterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression to play important roles in kidney disease. USAG-1 affects the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9752139 |
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| author | Xiaohu Li Wenlong Yue Guiwen Feng Jinfeng Li |
| author_facet | Xiaohu Li Wenlong Yue Guiwen Feng Jinfeng Li |
| author_sort | Xiaohu Li |
| collection | DOAJ |
| description | Uterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression to play important roles in kidney disease. USAG-1 affects the progression of acute and chronic kidney damage and the recovery of allograft kidney function by regulating the BMP and Wnt signaling pathways. Moreover, USAG-1 has been found to be involved in the process of T cell immune response, and its ability to inhibit germinal center activity and reduce humoral immunity is of great significance for the treatment of autoimmune nephropathy and antibody-mediated rejection (AMR) after renal transplantation. This article summarizes the many advances made regarding the roles of USAG-1 in the progression of kidney disease and outlines potential treatments. |
| format | Article |
| id | doaj-art-cb2607d625e94ecb81cf421a18045b63 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cb2607d625e94ecb81cf421a18045b632025-08-20T02:19:47ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/97521399752139Uterine Sensitization-Associated Gene-1 in the Progression of Kidney DiseasesXiaohu Li0Wenlong Yue1Guiwen Feng2Jinfeng Li3Department of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaUterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression to play important roles in kidney disease. USAG-1 affects the progression of acute and chronic kidney damage and the recovery of allograft kidney function by regulating the BMP and Wnt signaling pathways. Moreover, USAG-1 has been found to be involved in the process of T cell immune response, and its ability to inhibit germinal center activity and reduce humoral immunity is of great significance for the treatment of autoimmune nephropathy and antibody-mediated rejection (AMR) after renal transplantation. This article summarizes the many advances made regarding the roles of USAG-1 in the progression of kidney disease and outlines potential treatments.http://dx.doi.org/10.1155/2021/9752139 |
| spellingShingle | Xiaohu Li Wenlong Yue Guiwen Feng Jinfeng Li Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases Journal of Immunology Research |
| title | Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases |
| title_full | Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases |
| title_fullStr | Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases |
| title_full_unstemmed | Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases |
| title_short | Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases |
| title_sort | uterine sensitization associated gene 1 in the progression of kidney diseases |
| url | http://dx.doi.org/10.1155/2021/9752139 |
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