PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction

PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction

Abstract Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. The roles of PTEN‐induced kinase 1 (PINK1) and peroxiredoxin‐2 (Prdx2) in HFpEF pathogenesis remain unclear. Objective This study ai...

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Main Authors: Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Clinical and Translational Medicine
Online Access:https://doi.org/10.1002/ctm2.70166
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