Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway
Abstract The fine particulate matter (PM2.5) in air pollution is a critical risk factor influencing human health. Our study included 8144 participants and showed that the risk of major adverse cardiovascular events increases by 35% (HR, 1.35; 95% CI, 1.14–1.60) for participants with the highest quar...
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Wiley
2024-12-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202404142 |
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| author | Peier Chen Xiaodong Ning Weijing Feng Yajing Li Guoqin Chen Xu Shi YuXuan Pan Xueqin Shi Yafang Xiao Yuhua Liu Guoxia Zhang Feiran Zhou Caiwen Ou |
| author_facet | Peier Chen Xiaodong Ning Weijing Feng Yajing Li Guoqin Chen Xu Shi YuXuan Pan Xueqin Shi Yafang Xiao Yuhua Liu Guoxia Zhang Feiran Zhou Caiwen Ou |
| author_sort | Peier Chen |
| collection | DOAJ |
| description | Abstract The fine particulate matter (PM2.5) in air pollution is a critical risk factor influencing human health. Our study included 8144 participants and showed that the risk of major adverse cardiovascular events increases by 35% (HR, 1.35; 95% CI, 1.14–1.60) for participants with the highest quartile to PM2.5 exposure as compared to those with lowest quartile. Bioaerosols, as an important environmental exposure in PM2.5, can induce systemic chronic inflammation leading to vascular aging. Thus, the effects of bioaerosols are investigated from household garbage stations in PM2.5 on vascular aging, and the underlying mechanisms are explored. In vivo, chronic exposure to bioaerosols upregulated senescence marker expression levels while causing vascular dysfunction and remodeling. In vitro, bioaerosol exposure induced decreased proliferation, G0/G1 arrest, and impaired migration of human umbilical vein endothelial cells (HUVECs). Furthermore, a single bacterium (AS22a) from the bioaerosol community was isolated and demonstrated that it upregulated inflammatory factors and accelerated cell senescence and vascular aging by activating the NF‐κB/NLRP3 signaling pathway, which may serve as a primary mechanism underlying vascular aging induced by bioaerosols in PM2.5. These findings suggest that high levels of bioaerosols in household garbage stations may adversely affect cardiovascular health. |
| format | Article |
| id | doaj-art-cb205cf097314d6a95ffa23ee767f41a |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-cb205cf097314d6a95ffa23ee767f41a2025-08-20T02:19:01ZengWileyAdvanced Science2198-38442024-12-011145n/an/a10.1002/advs.202404142Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 PathwayPeier Chen0Xiaodong Ning1Weijing Feng2Yajing Li3Guoqin Chen4Xu Shi5YuXuan Pan6Xueqin Shi7Yafang Xiao8Yuhua Liu9Guoxia Zhang10Feiran Zhou11Caiwen Ou12The Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaDepartment of Cardiology State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaDepartment of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University Guangzhou 511400 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaDepartment of General Practice The Tenth Affiliated Hospital (Dongguan People's Hospital) Southern Medical University Dongguan 523059 ChinaDepartment of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University Guangzhou 510515 ChinaDepartment of Cardiology The First Hospital of Hunan University of Chinese Medicine Changsha 410007 ChinaThe Tenth Affiliated Hospital (Dongguan People's Hospital) The First School of Clinical Medicine Southern Medical University Dongguan 523059 ChinaAbstract The fine particulate matter (PM2.5) in air pollution is a critical risk factor influencing human health. Our study included 8144 participants and showed that the risk of major adverse cardiovascular events increases by 35% (HR, 1.35; 95% CI, 1.14–1.60) for participants with the highest quartile to PM2.5 exposure as compared to those with lowest quartile. Bioaerosols, as an important environmental exposure in PM2.5, can induce systemic chronic inflammation leading to vascular aging. Thus, the effects of bioaerosols are investigated from household garbage stations in PM2.5 on vascular aging, and the underlying mechanisms are explored. In vivo, chronic exposure to bioaerosols upregulated senescence marker expression levels while causing vascular dysfunction and remodeling. In vitro, bioaerosol exposure induced decreased proliferation, G0/G1 arrest, and impaired migration of human umbilical vein endothelial cells (HUVECs). Furthermore, a single bacterium (AS22a) from the bioaerosol community was isolated and demonstrated that it upregulated inflammatory factors and accelerated cell senescence and vascular aging by activating the NF‐κB/NLRP3 signaling pathway, which may serve as a primary mechanism underlying vascular aging induced by bioaerosols in PM2.5. These findings suggest that high levels of bioaerosols in household garbage stations may adversely affect cardiovascular health.https://doi.org/10.1002/advs.202404142bioaerosolgarbage stationNF‐κB/NLRP3PM2.5vascular aging |
| spellingShingle | Peier Chen Xiaodong Ning Weijing Feng Yajing Li Guoqin Chen Xu Shi YuXuan Pan Xueqin Shi Yafang Xiao Yuhua Liu Guoxia Zhang Feiran Zhou Caiwen Ou Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway Advanced Science bioaerosol garbage station NF‐κB/NLRP3 PM2.5 vascular aging |
| title | Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway |
| title_full | Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway |
| title_fullStr | Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway |
| title_full_unstemmed | Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway |
| title_short | Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway |
| title_sort | chronic exposure to bioaerosols in pm2 5 from garbage stations accelerates vascular aging via the nf κb nlrp3 pathway |
| topic | bioaerosol garbage station NF‐κB/NLRP3 PM2.5 vascular aging |
| url | https://doi.org/10.1002/advs.202404142 |
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