The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge
Chronic kidney disease (CKD) is becoming one of the world’s most prevalent noncommunicable chronic diseases. The World Health Organization projects CKD to become the 5th most common chronic disease in 2040. Causes of CKD are multifactorial and diverse, but early-stage symptoms are often few and sile...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2023/9609266 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546697922740224 |
|---|---|
| author | Rikke Borg Nicholas Carlson Jens Søndergaard Frederik Persson |
| author_facet | Rikke Borg Nicholas Carlson Jens Søndergaard Frederik Persson |
| author_sort | Rikke Borg |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is becoming one of the world’s most prevalent noncommunicable chronic diseases. The World Health Organization projects CKD to become the 5th most common chronic disease in 2040. Causes of CKD are multifactorial and diverse, but early-stage symptoms are often few and silent. Progression rates are highly variable, but patients encounter both an increased risk for end-stage kidney disease (ESKD) as well as increased cardiovascular risk. End-stage kidney disease incidence is generally low, but every single case carries a significant burden of illness and healthcare costs, making prevention by early intervention both desirable and worthwhile. This review focuses on the prevalence, diagnosis, and causes of CKD. In addition, we discuss the developments in the general treatment of CKD, with particular attention to what can be initiated in general practice. With the addition of recent landmark findings and the expansion of the indication for using sodium–glucose cotransporter 2 inhibitors, there are now new effective treatments to add to standard therapy. This will also be relevant for primary care physicians as many patients with CKD have their family physician as their primary health care professional handling kidney function preservation. In the future, more precise and less invasive diagnostic methods may not only improve the determination of the underlying cause of CKD but may also carry information regarding which treatment to use (i.e. personalized medicine). This could lead to a reduced number of preventive treatments per individual, while at the same time improving the prognosis. This review summarizes ongoing efforts in this area. |
| format | Article |
| id | doaj-art-cb2009f475a74f10a9dfcd63353141c2 |
| institution | Kabale University |
| issn | 2090-2158 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-cb2009f475a74f10a9dfcd63353141c22025-02-03T06:47:30ZengWileyInternational Journal of Nephrology2090-21582023-01-01202310.1155/2023/9609266The Growing Challenge of Chronic Kidney Disease: An Overview of Current KnowledgeRikke Borg0Nicholas Carlson1Jens Søndergaard2Frederik Persson3Department of NephrologyDepartment of NephrologyResearch Unit for General PracticeSteno Diabetes Center CopenhagenChronic kidney disease (CKD) is becoming one of the world’s most prevalent noncommunicable chronic diseases. The World Health Organization projects CKD to become the 5th most common chronic disease in 2040. Causes of CKD are multifactorial and diverse, but early-stage symptoms are often few and silent. Progression rates are highly variable, but patients encounter both an increased risk for end-stage kidney disease (ESKD) as well as increased cardiovascular risk. End-stage kidney disease incidence is generally low, but every single case carries a significant burden of illness and healthcare costs, making prevention by early intervention both desirable and worthwhile. This review focuses on the prevalence, diagnosis, and causes of CKD. In addition, we discuss the developments in the general treatment of CKD, with particular attention to what can be initiated in general practice. With the addition of recent landmark findings and the expansion of the indication for using sodium–glucose cotransporter 2 inhibitors, there are now new effective treatments to add to standard therapy. This will also be relevant for primary care physicians as many patients with CKD have their family physician as their primary health care professional handling kidney function preservation. In the future, more precise and less invasive diagnostic methods may not only improve the determination of the underlying cause of CKD but may also carry information regarding which treatment to use (i.e. personalized medicine). This could lead to a reduced number of preventive treatments per individual, while at the same time improving the prognosis. This review summarizes ongoing efforts in this area.http://dx.doi.org/10.1155/2023/9609266 |
| spellingShingle | Rikke Borg Nicholas Carlson Jens Søndergaard Frederik Persson The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge International Journal of Nephrology |
| title | The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge |
| title_full | The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge |
| title_fullStr | The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge |
| title_full_unstemmed | The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge |
| title_short | The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge |
| title_sort | growing challenge of chronic kidney disease an overview of current knowledge |
| url | http://dx.doi.org/10.1155/2023/9609266 |
| work_keys_str_mv | AT rikkeborg thegrowingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT nicholascarlson thegrowingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT jenssøndergaard thegrowingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT frederikpersson thegrowingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT rikkeborg growingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT nicholascarlson growingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT jenssøndergaard growingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge AT frederikpersson growingchallengeofchronickidneydiseaseanoverviewofcurrentknowledge |