Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement
The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking. The vast majority of studies have focused on CPP induced by il...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.154 |
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| author | Yu Liu Bernard Le Foll Yanli Liu Xi Wang Lin Lu |
| author_facet | Yu Liu Bernard Le Foll Yanli Liu Xi Wang Lin Lu |
| author_sort | Yu Liu |
| collection | DOAJ |
| description | The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking. The vast majority of studies have focused on CPP induced by illicit drugs, such as psychostimulants and opioids. Although legal psychoactive drugs, such as ethanol, nicotine, and caffeine, are more widely used than illegal drugs, the establishment, extinction, and reinstatement of CPP produced by these licit drugs are less well understood. The present review discusses the extant research on CPP induced by legal drugs. We first describe the CPP model and discuss the behavioral procedures used to induce CPP for ethanol, nicotine, and caffeine. We then summarize the neuronal substrates that underlie CPP induced by these drugs from a genetic perspective. Finally, we draw on findings from pharmacological studies and discuss the neurotransmitters and neurohormones underlying CPP produced by ethanol, nicotine, and caffeine. |
| format | Article |
| id | doaj-art-cb1dc4d5a88f4450ad264dfcec3abd90 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cb1dc4d5a88f4450ad264dfcec3abd902025-08-20T02:19:48ZengWileyThe Scientific World Journal1537-744X2008-01-0181228124510.1100/tsw.2008.154Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and ReinstatementYu Liu0Bernard Le Foll1Yanli Liu2Xi Wang3Lin Lu4National Institute on Drug Dependence, Peking University, Beijing, ChinaCentre for Addiction and Mental Health and University of Toronto, CanadaCollege of Pharmacy, Soochow University, Suzhou, ChinaNational Institute on Drug Dependence, Peking University, Beijing, ChinaNational Institute on Drug Dependence, Peking University, Beijing, ChinaThe conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking. The vast majority of studies have focused on CPP induced by illicit drugs, such as psychostimulants and opioids. Although legal psychoactive drugs, such as ethanol, nicotine, and caffeine, are more widely used than illegal drugs, the establishment, extinction, and reinstatement of CPP produced by these licit drugs are less well understood. The present review discusses the extant research on CPP induced by legal drugs. We first describe the CPP model and discuss the behavioral procedures used to induce CPP for ethanol, nicotine, and caffeine. We then summarize the neuronal substrates that underlie CPP induced by these drugs from a genetic perspective. Finally, we draw on findings from pharmacological studies and discuss the neurotransmitters and neurohormones underlying CPP produced by ethanol, nicotine, and caffeine.http://dx.doi.org/10.1100/tsw.2008.154 |
| spellingShingle | Yu Liu Bernard Le Foll Yanli Liu Xi Wang Lin Lu Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement The Scientific World Journal |
| title | Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement |
| title_full | Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement |
| title_fullStr | Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement |
| title_full_unstemmed | Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement |
| title_short | Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement |
| title_sort | conditioned place preference induced by licit drugs establishment extinction and reinstatement |
| url | http://dx.doi.org/10.1100/tsw.2008.154 |
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